This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.HDL are important vehicles for transporting cholesterol back to the liver for disposal. Serum opacity factor (SOF), a substance produced by strep bacteria, targets HDL and selectively removes lipids from the HDL particles, producing large cholesterol rich microemulsions (CERMs). SOF may be clinically useful, in production of more active HDL particles as well as moving cholesterol more efficiently to the liver. In this project we are studying the interaction of HDL with SOF and structurally characterizing the delipidation process.
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| Wensel, Theodore G; Zhang, Zhixian; Anastassov, Ivan A et al. (2016) Structural and molecular bases of rod photoreceptor morphogenesis and disease. Prog Retin Eye Res 55:32-51 |
| Bucero, Marta Abril; Bajaj, Chandrajit; Mourrain, Bernard (2016) On the construction of general cubature formula by flat extensions. Linear Algebra Appl 502:104-125 |
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