This investigation deals with the importance of low-barrier hydrogen bonds in the structure and function of enzymes. We need to synthesize a series of trifluormethyl ketone inhibitors and then characterize low-barrier hydrogen bonds between inhibitors and enzyme by NMR spectroscopic techniques. We also need to determine isotope effects and fractionation factors of these compounds.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002301-18
Application #
6575245
Study Section
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
18
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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