This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. MRI techniques like magnetization transfer (MT), chemical exchange saturation transfer (CEST) and magnetization exchange (ME) are being developed to explore the information about macromolecules and metabolites which cannot be imaged directly due to either ultra-short T2 or very low concentration. Z-spectrum data is used to study these phenomenons. Z-spectrum curve is mixed response of direct saturation (DS) of bulk water, MT, CEST, ME effects;quantification of individual components is essential however, challenging and has been a hot topic of research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002305-27
Application #
8362005
Study Section
Special Emphasis Panel (ZRG1-SBIB-Q (40))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
27
Fiscal Year
2011
Total Cost
$7,688
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ban, H Y; Schweiger, M; Kavuri, V C et al. (2016) Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry. Med Phys 43:4383
Finkelstein, Joel S; Lee, Hang; Leder, Benjamin Z et al. (2016) Gonadal steroid-dependent effects on bone turnover and bone mineral density in men. J Clin Invest 126:1114-25
Xie, Long; Dolui, Sudipto; Das, Sandhitsu R et al. (2016) A brain stress test: Cerebral perfusion during memory encoding in mild cognitive impairment. Neuroimage Clin 11:388-97
Rosenbaum, Michael; Leibel, Rudolph L (2016) Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring) 24:1620-9
McCarthy, Ann L; Winters, Madeline E; Busch, David R et al. (2015) Scoring system for periventricular leukomalacia in infants with congenital heart disease. Pediatr Res 78:304-9
Sharma, Anup; Newberg, Andrew B (2015) Mind-Body Practices and the Adolescent Brain: Clinical Neuroimaging Studies. Adolesc Psychiatry (Hilversum) 5:116-124
Samartzis, Dino; Borthakur, Ari; Belfer, Inna et al. (2015) Novel diagnostic and prognostic methods for disc degeneration and low back pain. Spine J 15:1919-32
Singh, Anup; Reddy, Damodar; Haris, Mohammad et al. (2015) T1ρ MRI of healthy and fibrotic human livers at 1.5 T. J Transl Med 13:292
Haris, Mohammad; Yadav, Santosh K; Rizwan, Arshi et al. (2015) T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease. Neuroimage Clin 7:598-604
Franklin, Teresa R; Jagannathan, Kanchana; Wetherill, Reagan R et al. (2015) Influence of menstrual cycle phase on neural and craving responses to appetitive smoking cues in naturally cycling females. Nicotine Tob Res 17:390-7

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