Crohn's disease and ulcerative colitis constitute the major forms of chronic inflammatory bowel diseases. These disorders occur in young adults with an estimated prevalence of more than 1/1000 inhabitants in western countries. Last year, our group reported a significant linkage of Crohn's disease to pericontromeric chromosome 16. This finding has since been replicated by four independent groups. A new European collaborative group has just been established to continue and expand the collection of Crohn's disease families from several European countries. These new families will assist current efforts to perform fine mapping of the chromosome 16 region and ultimately to isolate this gene. This large collection of families will also be used in further efforts to locate genes conferring susceptibility to Crohn's disease. ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR003655-15
Application #
6348113
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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