This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Differential sorting of endocytosed cargo into degradation or recycling pathways is a crucial feature of the endosomal system. PI3P effector proteins have been shown to mediate cargo sorting at early endosomes, but evidence is accumulating that PI3P binding proteins play important roles also later in the pathway. We are especially interested in sorting processes and membrane dynamics at the level of late endosomes, investigating candidate proteins by a variety of microscopy and biochemical techniques.
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