This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Activity in the thalamus triggers widespread cortical inhibition. This is not because thalamic neurons are inhibitory (they release the excitatory transmitter glutamate) but because they form powerful synapses with inhibitory interneurons in Layer IV of the cortex. We will examine the ultrastructure of these unusually strong connections in a joint light/electron microscopic study using dye labeling of both the thalamic inputs and their postsynaptic interneuron targets.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR004050-23
Application #
8361943
Study Section
Special Emphasis Panel (ZRG1-BST-R (40))
Project Start
2011-04-01
Project End
2012-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
23
Fiscal Year
2011
Total Cost
$24,666
Indirect Cost
Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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