We propose to establish a Center for Advanced Magnetic Resonance Technology at Stanford as a National Research Resource. The mission of the Center will be to develop and make available innovative technologies in five core research areas of magnetic resonance imaging and spectroscopy (MRI/MRS): (1) selective RF excitation, (2) rapid imaging methods, (3) imaging of microvasculature, (4) endogenous contrast mechanisms, and (5) quantitation and imaging of flow and motion. We will capitalize on our extensive experience in these MRI and MRS areas to improve and expand technology for better imaging in basic research and clinical care. Initial collaborative projects will include mapping of human brain functions with fMRI, studies of flow and myocardial motion, renal blood flow, blood flow dynamics, 1H metabolite imaging for aging and dementia, studies of infant heme catabolism and carbon monoxide detection, and functional maps of brain perfusion for ischemia and neuroscience investigations. Collaborations with numerous investigators provide a mutually beneficial environment for our continued development efforts. The Center's facilities and resources serve a wide base of users from medical and research institutions with sponsored research projects. With requested support, we will augment our animal experiment programs, equip the imaging magnets with high speed gradients and data acquisition systems, and develop additional instrumentation to expand our collaborative and service capabilities. We will continue to train students and postdoctoral fellows, to publish extensively, and to provide educational opportunities to the scientific and medical community. As a National Resource, we will publish a quarterly newsletter to highlight new developments and the capabilities at the Center, and distribute it in electronic and hardcopy form nationwide. New technological capabilities will be disseminated rapidly in electronic or hardcopy format for widespread use in the research community. We have collected a superb group of scientists and staff for this National Research Resource Center. At the present time, there is no center in the West Coast geographic region that can support the development of advanced MRI technology, especially as applied to biomedical imaging and with capabilities spanning the scale from NMR microscopy to whole-body applications. Our background In medical imaging innovation, coupled with our outstanding record of training scientists over the last three decades, makes Stanford ideally positioned to become the West Coast Resource Center for advanced magnetic resonance technology.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR009784-05S1
Application #
6204406
Study Section
Special Emphasis Panel (ZRG7 (18))
Program Officer
Levy, Abraham
Project Start
1995-01-01
Project End
2000-07-31
Budget Start
1999-01-01
Budget End
2000-07-31
Support Year
5
Fiscal Year
2000
Total Cost
$284,901
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Maclaren, Julian; Aksoy, Murat; Ooi, Melvyn B et al. (2018) Prospective motion correction using coil-mounted cameras: Cross-calibration considerations. Magn Reson Med 79:1911-1921
Guo, Jia; Holdsworth, Samantha J; Fan, Audrey P et al. (2018) Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study. J Magn Reson Imaging 47:1119-1132
Tamir, Jonathan I; Uecker, Martin; Chen, Weitian et al. (2017) T2 shuffling: Sharp, multicontrast, volumetric fast spin-echo imaging. Magn Reson Med 77:180-195
Lai, Lillian M; Cheng, Joseph Y; Alley, Marcus T et al. (2017) Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia. J Magn Reson Imaging 45:1407-1418
Taviani, Valentina; Alley, Marcus T; Banerjee, Suchandrima et al. (2017) High-resolution diffusion-weighted imaging of the breast with multiband 2D radiofrequency pulses and a generalized parallel imaging reconstruction. Magn Reson Med 77:209-220
Uecker, Martin; Lustig, Michael (2017) Estimating absolute-phase maps using ESPIRiT and virtual conjugate coils. Magn Reson Med 77:1201-1207
Kogan, Feliks; Hargreaves, Brian A; Gold, Garry E (2017) Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho. Magn Reson Med 77:1134-1141
Aksoy, Murat; Maclaren, Julian; Bammer, Roland (2017) Prospective motion correction for 3D pseudo-continuous arterial spin labeling using an external optical tracking system. Magn Reson Imaging 39:44-52
Bian, W; Tranvinh, E; Tourdias, T et al. (2016) In Vivo 7T MR Quantitative Susceptibility Mapping Reveals Opposite Susceptibility Contrast between Cortical and White Matter Lesions in Multiple Sclerosis. AJNR Am J Neuroradiol 37:1808-1815
Vos, Sjoerd B; Aksoy, Murat; Han, Zhaoying et al. (2016) Trade-off between angular and spatial resolutions in in vivo fiber tractography. Neuroimage 129:117-132

Showing the most recent 10 out of 446 publications