This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Diffusion-weighted imaging (DWI) using echo-planar imaging (EPI) has been limited by geometric distortion and blurring, particularly in regions with large off-resonance effects such as in the spinal-cord and in regions of the brain residing near tissue/air interfaces. Geometric distortion in EPI is proportional to the FOV in the phase encoding direction (FOVpe), as well as the echo-spacing between adjacent echoes in the EPI train (Tro). To reduce FOVpe and avoid aliasing, here we use the zonal oblique multislice EPI (ZOOM-EPI) technique, which uses a tilted refocusing pulse. To reduce distortion further, Tro can be reduced by covering k-space with a series of consecutive segments or 'blinds', known as RS-EPI. Here we implemented the ZOOM pulse together with the RS-EPI trajectory (ZOOM-RS-EPI) to get the benefits of both methods for reducing distortion.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009784-17
Application #
8362958
Study Section
Special Emphasis Panel (ZRG1-SBIB-U (40))
Project Start
2011-04-01
Project End
2012-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
17
Fiscal Year
2011
Total Cost
$19,531
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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