Abstract

It is known that the presence of infarcted regions of myocardium can result in fatal arrhythmias with little or no warning. This project seeks to correlate the 3-dimensional configuration of infarcts with onset of sudden arrhythmia. This will be done initially using high-resolution (0.2-0.3mm spatial resolution) isotropic 3D NMR imaging at high field of fixed human hearts. High field imaging will permit acquisition of images with adequate signal-to-noise ratio while maintaining very high spatial resolution. Initial experiments have demonstrated the ability to clearly visualize infarcted regions within (what had been) normal tissue of fixed hearts (formalin) using T1 weighted NMR imaging. This study may lead to high resolution ventricular function imaging of paced infarct animal models using imaging techniques developed under Core Project III (Imaging of Physiological Function).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR011811-03
Application #
6123456
Study Section
Project Start
1999-05-01
Project End
2000-02-29
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Sirikul, Bovorn; Hunter, Gary R; Larson-Meyer, D Enette et al. (2007) Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction. Appl Physiol Nutr Metab 32:394-9
Redden, David T; Divers, Jasmin; Vaughan, Laura Kelly et al. (2006) Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. PLoS Genet 2:e137
Elgavish, Rotem A; Twieg, Donald B (2003) Improved depiction of small anatomic structures in MR images using Gaussian-weighted spirals and zero-filled interpolation. Magn Reson Imaging 21:103-12
Twieg, Donald B (2003) Parsing local signal evolution directly from a single-shot MRI signal: a new approach for fMRI. Magn Reson Med 50:1043-52
Larson-Meyer, D Enette; Newcomer, Bradley R; Hunter, Gary R (2002) Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am J Physiol Endocrinol Metab 282:E95-E106
Newcomer, B R; Larson-Meyer, D E; Hunter, G R et al. (2001) Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using (31)P magnetic resonance spectroscopy. Int J Obes Relat Metab Disord 25:1309-15
Newman, S D; Twieg, D B; Carpenter, P A (2001) Baseline conditions and subtractive logic in neuroimaging. Hum Brain Mapp 14:228-35
Newman, S D; Twieg, D (2001) Differences in auditory processing of words and pseudowords: an fMRI study. Hum Brain Mapp 14:39-47
Patton, H K; Chu, W J; Hetherington, H P et al. (2001) Alkaline pH changes in the cerebellum of asymptomatic HIV-infected individuals. NMR Biomed 14:12-8
Larson-Meyer, D E; Newcomer, B R; Hunter, G R et al. (2001) Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism. Muscle Nerve 24:1665-76

Showing the most recent 10 out of 19 publications