Ordinarily, the lack of higher k-space values causes a blurring artifact in the reconstructed images in which sharp discontinuities create spatial oscillations into nearby regions. In some cases - such as lipids in the scalp - these discontinuities con interfere with low-level signal measurements in nearby regions. If the general location of these bright signals is known, we can postprocess the image to """"""""steer"""""""" the oscillations in a different direction. We have developed a simple approach to solving this problem. By specifying the location of the bright interference, the phase response of a filter is optimized to reduce the oscillations in the region of interest. At present, out technique has been verified in 1-D simulations. It holds promise for significantly reducing the oscillations caused by nearby bright objects. The computational complexity - once the filter has been designed - is on the same order as the original reconstruction from k-space samples. We are currently extending the method to 2-D and more general interference patterns. We investigated the use of a local variance model of the image to indicate a priori knowledge of discontinuities in the original. The model separately represented variations in the horizontal direction and the vertical direction. We assumed that an accurate model could be derived from a standard MR scout image of the object. The local variance model was incorporated into the reconstruction by penalizing roughness in a way inversely related to the local variance of the scout image. In this way, the reconstruction formula was made to be shift variant, allowing for the possibility of spectral extrapolation from the observed k-space samples. Our experiments confirmed that this is a very effective form of image model for the type of prior information that is available from an anatomic scout image. While higher resolution of fine details was somewhat limited, the reconstruction was dramatically sharper near boundaries in the image so that blurring of edges was minimal.?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR011811-04
Application #
6324826
Study Section
Project Start
2000-06-15
Project End
2001-02-28
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2000
Total Cost
$66,897
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Sirikul, Bovorn; Hunter, Gary R; Larson-Meyer, D Enette et al. (2007) Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction. Appl Physiol Nutr Metab 32:394-9
Redden, David T; Divers, Jasmin; Vaughan, Laura Kelly et al. (2006) Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. PLoS Genet 2:e137
Elgavish, Rotem A; Twieg, Donald B (2003) Improved depiction of small anatomic structures in MR images using Gaussian-weighted spirals and zero-filled interpolation. Magn Reson Imaging 21:103-12
Twieg, Donald B (2003) Parsing local signal evolution directly from a single-shot MRI signal: a new approach for fMRI. Magn Reson Med 50:1043-52
Larson-Meyer, D Enette; Newcomer, Bradley R; Hunter, Gary R (2002) Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am J Physiol Endocrinol Metab 282:E95-E106
Newcomer, B R; Larson-Meyer, D E; Hunter, G R et al. (2001) Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using (31)P magnetic resonance spectroscopy. Int J Obes Relat Metab Disord 25:1309-15
Newman, S D; Twieg, D B; Carpenter, P A (2001) Baseline conditions and subtractive logic in neuroimaging. Hum Brain Mapp 14:228-35
Newman, S D; Twieg, D (2001) Differences in auditory processing of words and pseudowords: an fMRI study. Hum Brain Mapp 14:39-47
Patton, H K; Chu, W J; Hetherington, H P et al. (2001) Alkaline pH changes in the cerebellum of asymptomatic HIV-infected individuals. NMR Biomed 14:12-8
Larson-Meyer, D E; Newcomer, B R; Hunter, G R et al. (2001) Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism. Muscle Nerve 24:1665-76

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