This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Track-HD is a multi-centre, multi-national prospective observational biomarker study in pre-manifest disease persons and early Huntington's disease patients, funded by the High Q Foundation. The primary objective of Track-HD is to determine what combination of measures is the most sensitive for detecting change during the natural course of pre-manifest and early HD. These will be validated as potential outcome measures for use in future disease-modifying drug trials. Some of these measures are morphometric image analysis techniques on MR brain volumes. In order to get the best images for analysis in this study, we are initiating a sequence optimization process for 3T images, in which we test MR sequences before choosing the protocol for the study. We are also assembling an Advisory Group of interested parties and imaging experts to ensure that this is an open process which compiles as many viable options for the sequence as possible. Sequence optimization for the imaging component of the TRACK-HD study will be conducted at 3T on Philips and Siemens scanners. It is anticipated that a T1-weighted (T1W) volume will be acquired on which standard image analysis procedures will be used. As a more exploratory step, a T2 volume will also be acquired. Our goal is to develop a sequence that can be used for more than just establishing pathology through a clinical read;it will allow interested groups to explore image analysis techniques.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR013642-14
Application #
8363476
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (40))
Project Start
2011-08-01
Project End
2012-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
14
Fiscal Year
2011
Total Cost
$20,271
Indirect Cost
Name
University of California Los Angeles
Department
Neurology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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