In this application we seek renewed support for our continued efforts to develop innovative neuroimaging technologies within the highly integrated multimodal framework of our P41 Regional Resource, the Center for Functional Neuroimaging Technologies (CFNT). The overarching goal of the CFNT is to provide technology Resources to more closely examine and better understand the human brain in both health and disease. To this end, we seek to develop new techniques and advance existing technologies for acquisition and analysis of functionally specific images of the working brain, with unprecedented physiological precision and spatiotemporal resolution. To accomplish this goal, we propose to continue our core and collaborative research, service, training and dissemination activities. Central to this effort are our four core technology research and development projects, designed to improve and extend techniques for non-invasive magnetic resonance image analysis (Project 1) and acquisition (Project 2), electromagnetic source imaging (Project 3), and optical neuroimaging (Project 4). New for this cycle, an exciting new technology, integrated PET/MRI will be explored within several of these projects. The Resource provides an essential interactive environment, within which an interdisciplinary team of highly skilled scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines collaborate closely with our Center to advance the technical capabilities of the Center, while reciprocally enhancing their own research by applying the tools we co-develop. Finally, the Resource will continue to support service use of the Center's facilities by neuroscientists throughout the country, provide extensive training opportunities for students, fellows, and staff scientists, and seek to advance the field of brain mapping through active dissemination of new knowledge and technology.

Public Health Relevance

The P41 Resource, by actively developing cutting-edge neuroimaging technologies, conducting collaborative research involving applications of these technologies, and extending them for service use to the broader neuroscientific research community, has extensive potential to help shape the basic neuroscience and translational research landscape. Ultimately, this work may thus facilitate the development of new therapeutic advances for an astounding array of neurological and psychiatric diseases.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR014075-13
Application #
8098820
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (40))
Program Officer
Levy, Abraham
Project Start
2000-09-01
Project End
2014-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
13
Fiscal Year
2011
Total Cost
$1,198,240
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Zhao, Wenjun; Lee, Hong Geun; Buchwald, Stephen L et al. (2017) Direct 11CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions. J Am Chem Soc 139:7152-7155
Vasung, Lana; Raguz, Marina; Kostovic, Ivica et al. (2017) Spatiotemporal Relationship of Brain Pathways during Human Fetal Development Using High-Angular Resolution Diffusion MR Imaging and Histology. Front Neurosci 11:348
Kalpathy-Cramer, Jayashree; Chandra, Vyshak; Da, Xiao et al. (2017) Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. J Neurooncol 131:603-610
Walton, E; Hibar, D P; van Erp, T G M et al. (2017) Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatr Scand 135:439-447
Mekkaoui, Choukri; Reese, Timothy G; Jackowski, Marcel P et al. (2017) Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging. Radiology 282:850-856
Cohen, Ouri; Zhao, Ming; Nevo, Erez et al. (2017) MR Coagulation: A Novel Minimally Invasive Approach to Aneurysm Repair. J Vasc Interv Radiol 28:1592-1598
Coutinho, Artur Martins; Coutu, Jean-Philippe; Lindemer, Emily Rose et al. (2017) Differential associations between systemic markers of disease and cortical thickness in healthy middle-aged and older adults. Neuroimage 146:19-27
Cauley, Stephen F; Setsompop, Kawin; Bilgic, Berkin et al. (2017) Autocalibrated wave-CAIPI reconstruction; Joint optimization of k-space trajectory and parallel imaging reconstruction. Magn Reson Med 78:1093-1099
Coutu, Jean-Philippe; Lindemer, Emily R; Konukoglu, Ender et al. (2017) Two distinct classes of degenerative change are independently linked to clinical progression in mild cognitive impairment. Neurobiol Aging 54:1-9
Dagley, Alexander; LaPoint, Molly; Huijbers, Willem et al. (2017) Harvard Aging Brain Study: Dataset and accessibility. Neuroimage 144:255-258

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