This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Successful realization of the Center's high-power 35 GHz FT-ESR pulse spectrometer mandates inclusion of fast, high-attenuation radiofrequency (r.f.) switching for receiver protection. As described elsewhere (Subproject: Development of Receiver Protector for 35 GHz Pulsed ESR), we have previously developed a prototype ferrite-based circulator/isolator waveguide r.f. switch for receiver protection in the 35 GHz frequency regime. A crucial element in realization of this fast r.f. switch subsystem is our design and assembly of a solid-state high-voltage driver capable of delivering an extraordinarily rapid, high value current transition through the switch?s inductive ferrite element. In order to adequately protect the receiver, this ultrafast-switching application requires that the driver must provide a rectangular pulse of FWHM 20 nsec with a compliance of 1200 volts and a peak value of approximately 25 amperes. Our previous experience in simulation and evaluation of driver parameters for high-speed switching has been utilized in determining that a pulse-forming network (PFN) would be the preferred solution to the challenging driver performance conditions specified. In the preliminary design analysis, we noted that the PFN's inherent charge/discharge symmetry could also be exploited to provide the needed complementary reset pulse. Of the possible PFN topologies in combination with the various characteristic impedances which we simulated for evaluation and optimization, we have determined that the Type A Guilleman form at 36 ohms best meets our requirements. When coupled to a suitably fast h.v. switch, we observe that our prototype 3-stage PFN driver causes the circulator/isolator to switch incident r.f. energy in a notably short interval of 10 ? 20 ns. We are presently characterizing the 35GHz receiver protection requirements in terms of the spectrometer bridge r.f. parameters and, on the basis of this information;we will then conduct a final design refinement of the h.v. switch parameters for this application.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR016292-11
Application #
8363940
Study Section
Special Emphasis Panel (ZRG1-BCMB-K (40))
Project Start
2011-09-01
Project End
2012-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
11
Fiscal Year
2011
Total Cost
$488
Indirect Cost
Name
Cornell University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Jain, Rinku; Vanamee, Eva S; Dzikovski, Boris G et al. (2014) An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ?. J Mol Biol 426:301-8
Pratt, Ashley J; Shin, David S; Merz, Gregory E et al. (2014) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes. Proc Natl Acad Sci U S A 111:E4568-76
Georgieva, Elka R; Borbat, Peter P; Ginter, Christopher et al. (2013) Conformational ensemble of the sodium-coupled aspartate transporter. Nat Struct Mol Biol 20:215-21
Airola, Michael V; Sukomon, Nattakan; Samanta, Dipanjan et al. (2013) HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors. PLoS Biol 11:e1001479
Airola, Michael V; Huh, Doowon; Sukomon, Nattakan et al. (2013) Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling. J Mol Biol 425:886-901
Sun, Yan; Zhang, Ziwei; Grigoryants, Vladimir M et al. (2012) The internal dynamics of mini c TAR DNA probed by electron paramagnetic resonance of nitroxide spin-labels at the lower stem, the loop, and the bulge. Biochemistry 51:8530-41
Smith, Andrew K; Freed, Jack H (2012) Dynamics and ordering of lipid spin-labels along the coexistence curve of two membrane phases: an ESR study. Chem Phys Lipids 165:348-61
Yu, Renyuan Pony; Darmon, Jonathan M; Hoyt, Jordan M et al. (2012) High-Activity Iron Catalysts for the Hydrogenation of Hindered, Unfunctionalized Alkenes. ACS Catal 2:1760-1764
Gaffney, Betty J; Bradshaw, Miles D; Frausto, Stephen D et al. (2012) Locating a lipid at the portal to the lipoxygenase active site. Biophys J 103:2134-44
Dzikovski, Boris; Tipikin, Dmitriy; Freed, Jack (2012) Conformational distributions and hydrogen bonding in gel and frozen lipid bilayers: a high frequency spin-label ESR study. J Phys Chem B 116:6694-706

Showing the most recent 10 out of 72 publications