This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ACERT presently possesses 5 c.w. and 1 pulsed millimeter-wave sources, ranging in output power from approximately 1mW to 1.2KW. During the course of the Center grant period, we have increasingly required qualification, maintenance, and calibration services for these sources. To this end, we have assembled test and measurement instrumentation necessary to accomplish this task, and have established a regimen for applying these tools to it. The fundamental measurements are power, wavelength/frequency, spectral characteristics (including noise power) and, for pulse devices, temporal response. To address these needs, a test area has been set aside where the necessary measurement setups may be faithfully and quickly reproduced. For our quasioptical power measurements, we rely on a Thomas Keating Ltd. """"""""TK TeraHertz"""""""" incident power meter system, with an absolute calibration accuracy of approximately 20% when corrected for wavelength and beam profile. Frequency and spectral characteristics are measured by means of a Tektronix model 492 spectrum analyzer, using a set of calibrated harmonic waveguide detectors covering 20 through 325 GHz. Because the TK power meter is relatively insensitive to wavelength, it produces a calibrated power measurement which is not highly sensitive to nor revealing with respect to the actual operating frequency. The spectrum analyzer, on the other hand, produces a relatively accurate measurement of the operating frequency and good qualitative measurement of the actual output spectrum, but is poorly calibrated with respect to absolute power at a given frequency. Between the two measurement systems, however, a good complementary measurement of power, wavelength/frequency and spectral characteristics is achievable. Temporal response is measured either by direct observation of an appropriate waveguide harmonic mixer output in detector mode, or indirectly, by interpretation of the frequency-domain spectrum observed with the spectrum analyzer.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BCMB-K (40))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cornell University
Schools of Arts and Sciences
United States
Zip Code
Jain, Rinku; Vanamee, Eva S; Dzikovski, Boris G et al. (2014) An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ?. J Mol Biol 426:301-8
Pratt, Ashley J; Shin, David S; Merz, Gregory E et al. (2014) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes. Proc Natl Acad Sci U S A 111:E4568-76
Georgieva, Elka R; Borbat, Peter P; Ginter, Christopher et al. (2013) Conformational ensemble of the sodium-coupled aspartate transporter. Nat Struct Mol Biol 20:215-21
Airola, Michael V; Sukomon, Nattakan; Samanta, Dipanjan et al. (2013) HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors. PLoS Biol 11:e1001479
Airola, Michael V; Huh, Doowon; Sukomon, Nattakan et al. (2013) Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling. J Mol Biol 425:886-901
Sun, Yan; Zhang, Ziwei; Grigoryants, Vladimir M et al. (2012) The internal dynamics of mini c TAR DNA probed by electron paramagnetic resonance of nitroxide spin-labels at the lower stem, the loop, and the bulge. Biochemistry 51:8530-41
Yu, Renyuan Pony; Darmon, Jonathan M; Hoyt, Jordan M et al. (2012) High-Activity Iron Catalysts for the Hydrogenation of Hindered, Unfunctionalized Alkenes. ACS Catal 2:1760-1764
Dzikovski, Boris; Tipikin, Dmitriy; Freed, Jack (2012) Conformational distributions and hydrogen bonding in gel and frozen lipid bilayers: a high frequency spin-label ESR study. J Phys Chem B 116:6694-706
Gaffney, Betty J; Bradshaw, Miles D; Frausto, Stephen D et al. (2012) Locating a lipid at the portal to the lipoxygenase active site. Biophys J 103:2134-44
Maeda, Kiminori; Lodge, Matthew T J; Harmer, Jeffrey et al. (2012) Electron tunneling in lithium-ammonia solutions probed by frequency-dependent electron spin relaxation studies. J Am Chem Soc 134:9209-18

Showing the most recent 10 out of 72 publications