Project 6: Oxidative Remediation of Recalcitrant Contaminants with Persulfate. Persulfate (S20s^) is a relatively inexpensive reagent that can be used to oxidize many of the most recalcitrant contaminants present at hazardous waste sites. Although it is becoming more popular for hazardous waste site remediation, the chemical reactions through which persulfate oxidizes contaminants are not well understood. The overall goal of our research is to develop and test new approaches for oxidizing contaminants that are difficult to treat with existing technologies (e.g., PCBs, 1,4-dioxane and PFOA) and apply it to make treatment systems more robust and efficient. Through the use of kinetic models and detailed research on reaction mechanisms, we will develop the means of predicting contaminant transformation rates and optimizing system performance. This mechanistic understanding of persulfate chemistry will require that we build increasing complexity into our model in stages. Initially, we will calibrate our kinetic model for the homogeneous reactions through which persulfate is converted into oxidants using experiments with various compounds that react predominantly with sulfate radical or hydroxyl radical. After calibrating the model over the range of conditions likely to be encountered during remediation, we will investigate the role of heterogeneous reactions of iron-containing solids on the initiation of radical production. By applying findings from experiments in heterogeneous systems with state-of-the-art surface characterization techniques we will synthesize new types of heterogeneous catalysts for ex situ treatment of contaminated groundwater. We also will use results from the heterogeneous experiments to improve the predictive ability ofthe model and identify optimal conditions for remediation. After defining the conditions that are best suited for contaminant remediation, we will assess the potential formation of toxic intermediate products during the remediation process using high content screening assays and mass spectrometry. Our research will lead to a mechanistic understanding of persulfate chemistry that should, in turn, lead to a level of understanding that will allow engineers to avoid excessive use of reagents and the formation of toxic intermediates when persulfate is used for remediation.

Public Health Relevance

Successful completion of the proposed research will result in new oxidative treatment systems that will substantially reduce the costs of remediating contaminants that are difficult to treat with existing technologies. Our research will also result in the development of a better understanding of when ISCO will be effective, thereby facilitating the broader application ofthe technology and a reduction in public health risks at hazardous waste sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004705-27
Application #
8659378
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
27
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Counihan, Jessica L; Ford, Breanna; Nomura, Daniel K (2016) Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol 30:68-76
Shen, Hua; McHale, Cliona M; Haider, Syed I et al. (2016) Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci 154:194
Smith, Martyn T; Guyton, Kathryn Z; Gibbons, Catherine F et al. (2016) Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect 124:713-21
Hsu, Ling-I; Briggs, Farren; Shao, Xiaorong et al. (2016) Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol Biomarkers Prev 25:815-22
Carlos-Wallace, Frolayne M; Zhang, Luoping; Smith, Martyn T et al. (2016) Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis. Am J Epidemiol 183:1-14
Liu, Haizhou; Bruton, Thomas A; Li, Wei et al. (2016) Oxidation of Benzene by Persulfate in the Presence of Fe(III)- and Mn(IV)-Containing Oxides: Stoichiometric Efficiency and Transformation Products. Environ Sci Technol 50:890-8
Barazesh, James M; Prasse, Carsten; Sedlak, David L (2016) Electrochemical Transformation of Trace Organic Contaminants in the Presence of Halide and Carbonate Ions. Environ Sci Technol 50:10143-52
Shen, Hua; McHale, Cliona M; Haider, Syed I et al. (2016) Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci 151:10-22
Hu, Xindi C; Andrews, David Q; Lindstrom, Andrew B et al. (2016) Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants. Environ Sci Technol Lett 3:344-350
Bailey, Kathryn A; Smith, Allan H; Tokar, Erik J et al. (2016) Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps. Environ Health Perspect 124:170-5

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