Naturally occurring and anthropogenic pollutants adversely affect human and ecosystem health. Knowledge from biomedical research is not utilized to its maximum potential unless it is effectively communicated in an understandable manner to health professionals, government regulatory agencies, industry and other end users, or stakeholders. We hypothesize that effective bidirectional communication between research scientists and stakeholders of research findings will improve the research being conducted by scientists provide more relevant information for regulatory agencies, enhance the overall benefits of this research, and ultimately lead to the best possible solutions to existing environmental problems. The Michigan State University (MSU) Superfund Research Program (SRP) Center focuses on the toxicology and environmental fate of dioxin and dioxin-like compounds (DLC), which have been identified as environmental contaminants in the Tri-Cities (Saginaw, Midland, Bay City) area in Michigan. The MSU SRP Center Research Translation Core (RTC) will serve as a bidirectional bridge for disseminating information, technology transfer and educational activities between the MSU SRP Center and key stakeholders. Specifically, our stakeholders are State government agencies, including Michigan Department Environment Quality (MDEQ) and Michigan Department of Agriculture Michigan Department of Agriculture and Rural Development (MDARD), Federal government agencies, including the United States Environmental Protection Agency (USEPA) Region 5 and the Agency for Toxic Substances and Disease Registry (ATSDR), and industry, such as the Sediment Management Working Group (SMWG). Ultimately, the most important stakeholders are the residents in communities in which environmental contamination exists and therefore, we have identified health professionals in community-based hospitals as novel stakeholders since they can be critical conduits of research translation. Training of health professionals will occur at the Flint and Midland Regional Campuses of the MSU College of Human Medicine. This aforementioned consortium of stakeholders provides a unique opportunity for scientists from government, industry and academia to collaborate on solutions to complex environmental problems surrounding dioxin and DLC in the State of Michigan. Toward this end, the above stated hypothesis will be tested by: (a) using well-established communication tools;(b) partnering with government and industry;(c) transferring technology using novel mechanisms;and (d) providing educational resources.

Public Health Relevance

Knowledge from health-related research is not utilized to its maximum potential unless it is effectively communicated in an understandable manner to health professionals, government regulatory agencies, industry, the community, and other stakeholders. The Research Translation Core will facilitate the flow of information between basic-science being conducted by the MSU SRP Center and key stakeholders to minimize the health hazards of dioxin and dioxin-like compounds to humans and the environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES004911-22A1
Application #
8565737
Study Section
Special Emphasis Panel (ZES1-LWJ-D (SF))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
22
Fiscal Year
2013
Total Cost
$180,235
Indirect Cost
$62,818
Name
Michigan State University
Department
Type
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Hwang, Hye Jin; Dornbos, Peter; Steidemann, Michelle et al. (2016) Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol 304:121-32
Hwang, Hye Jin; Dornbos, Peter; LaPres, John J (2016) Data on AHR-dependent changes in the mitochondrial proteome in response to ,3,7,8-tetrachlorodibenzo-p-dioxin. Data Brief 8:191-5
Stedtfeld, Robert D; Williams, Maggie R; Fakher, Umama et al. (2016) Antimicrobial resistance dashboard application for mapping environmental occurrence and resistant pathogens. FEMS Microbiol Ecol 92:
Kovalova, Natalia; Manzan, Maria; Crawford, Robert et al. (2016) Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells. Toxicol Appl Pharmacol 309:15-23
Tian, Haoting; Gao, Juan; Li, Hui et al. (2016) Complete Defluorination of Perfluorinated Compounds by Hydrated Electrons Generated from 3-Indole-acetic-acid in Organomodified Montmorillonite. Sci Rep 6:32949
Phadnis-Moghe, Ashwini S; Li, Jinpeng; Crawford, Robert B et al. (2016) SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol 310:41-50
Nault, Rance; Fader, Kelly A; Kirby, Mathew P et al. (2016) Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Toxicol Sci 149:358-71
Wang, Qiong; Fish, Jordan A; Gilman, Mariah et al. (2015) Xander: employing a novel method for efficient gene-targeted metagenomic assembly. Microbiome 3:32
Nault, Rance; Colbry, Dirk; Brandenberger, Christina et al. (2015) Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicol Pathol 43:366-75
Liu, Cun; Gu, Cheng; Yu, Kai et al. (2015) Integrating structural and thermodynamic mechanisms for sorption of PCBs by montmorillonite. Environ Sci Technol 49:2796-805

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