The Community Engagement Core will partner with Michigan State University (MSU) Extension in the Michigan Tri-Cities region (Saginaw, Midland, and Bay City) to strengthen social networks, enhance community knowledge about the state-of-the-science including knowledge about health risks associated with exposure to dioxin and dioxin-like compounds, and facilitate decision-making around reducing environmental health risks. We propose identifying key actors and stakeholders in the area, then holding a series of workshops between these key actors and MSU SRP researchers. The workshops have three main objectives: 1) To bring diverse stakeholders together in a face-to-face, interactive setting in order to strengthen relationships and community capacity to address local environmental health problems;2) to provide education about the scientific method, and how dioxin and dioxin-like compounds interact in the body and in the environment;and 3) to increase MSU SRP researchers'understanding of community questions and concerns about health risks associated with dioxin exposure and the forces beyond science that shape public policy. Each annual series of workshops will cumulate in a white paper or MSU Extension factsheet identifying common questions and summarizing concerns and possible solutions. The white papers and/or factsheets will be published online via the MSU SPR website and the MSU Extension website. Printed versions will be made available in district libraries, county public health offices, and MSU Extension offices. Summaries of these papers also will be available through a mobile phone """"""""app"""""""" developed by the MSU SRP RTC. Long-term outcomes of these workshops may include community identification of research strategies for addressing dioxins at the whole system, community, and human health levels, as well as agreement on cleanup criteria.

Public Health Relevance

MSU Extension will host and facilitate community dialogue to establish an understanding of the specific needs of the public concerning dioxin contamination within their community. Using online and face-to-face forums, MSU Extension community development educators will enhance the lay public's knowledge concerning the current state-of-the-science on dioxin-related health effects and also data gaps. This two-way communication will educate the community and MSU investigators enabling informed decision-making by all.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Michigan State University
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Nault, Rance; Doskey, Claire M; Fader, Kelly A et al. (2018) Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol 94:876-884
Dornbos, Peter; LaPres, John J (2018) Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8
Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Interfacial Structure and Interaction of Kaolinite Intercalated with N-methylformamide Insight from Molecular Dynamics Modeling. Appl Clay Sci 158:204-210
Fader, Kelly A; Nault, Rance; Raehtz, Sandi et al. (2018) 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98
Zhang, Shuai; Liu, Qinfu; Cheng, Hongfei et al. (2018) Mechanism Responsible for Intercalation of Dimethyl Sulfoxide in Kaolinite: Molecular Dynamics Simulations. Appl Clay Sci 151:46-53
Zhang, Qiang; Li, Jin; Middleton, Alistair et al. (2018) Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. Front Public Health 6:261
Fader, K A; Nault, R; Kirby, M P et al. (2018) Corrigendum to ""Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERB?/? activation in aryl hydrocarbon receptor-elicited hepatotoxicity"" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17]. Toxicol Appl Pharmacol 344:74
Konganti, Kranti; Ehrlich, Andre; Rusyn, Ivan et al. (2018) gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3 (Bethesda) 8:2559-2562
Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Molecular Dynamics Simulation of Basal Spacing, Energetics, and Structure Evolution of a Kaolinite-Formamide Intercalation Complex and Their Interfacial Interaction. J Phys Chem C Nanomater Interfaces 122:3341-3349
Williams, M R; Stedtfeld, R D; Waseem, H et al. (2017) Implications of direct amplification for measuring antimicrobial resistance using point-of-care devices. Anal Methods 9:1229-1241

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