Naturally occurring and anthropogenic pollutants adversely affect human and ecosystem health. Knowledge from biomedical research is not utilized to its maximum potential unless it is effectively communicated in an understandable manner to health professionals, government regulatory agencies, industry and other end users, or stakeholders. We hypothesize that effective bidirectional communication between research scientists and stakeholders of research findings will improve the research being conducted by scientists provide more relevant information for regulatory agencies, enhance the overall benefits of this research, and ultimately lead to the best possible solutions to existing environmental problems. The Michigan State University (MSU) Superfund Research Program (SRP) Center focuses on the toxicology and environmental fate of dioxin and dioxin-like compounds (DLC), which have been identified as environmental contaminants in the Tri-Cities (Saginaw, Midland, Bay City) area in Michigan. The MSU SRP Center Research Translation Core (RTC) will serve as a bidirectional bridge for disseminating information, technology transfer and educational activities between the MSU SRP Center and key stakeholders. Specifically, our stakeholders are State government agencies, including Michigan Department Environment Quality (MDEQ) and Michigan Department of Agriculture Michigan Department of Agriculture and Rural Development (MDARD), Federal government agencies, including the United States Environmental Protection Agency (USEPA) Region 5 and the Agency for Toxic Substances and Disease Registry (ATSDR), and industry, such as the Sediment Management Working Group (SMWG). Ultimately, the most important stakeholders are the residents in communities in which environmental contamination exists and therefore, we have identified health professionals in community-based hospitals as novel stakeholders since they can be critical conduits of research translation. Training of health professionals will occur at the Flint and Midland Regional Campuses of the MSU College of Human Medicine. This aforementioned consortium of stakeholders provides a unique opportunity for scientists from government, industry and academia to collaborate on solutions to complex environmental problems surrounding dioxin and DLC in the State of Michigan. Toward this end, the above stated hypothesis will be tested by: (a) using well-established communication tools;(b) partnering with government and industry;(c) transferring technology using novel mechanisms;and (d) providing educational resources.

Public Health Relevance

Knowledge from health-related research is not utilized to its maximum potential unless it is effectively communicated in an understandable manner to health professionals, government regulatory agencies, industry, the community, and other stakeholders. The Research Translation Core will facilitate the flow of information between basic-science being conducted by the MSU SRP Center and key stakeholders to minimize the health hazards of dioxin and dioxin-like compounds to humans and the environment.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LWJ-D)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Michigan State University
East Lansing
United States
Zip Code
Cole, James R; Tiedje, James M (2014) History and impact of RDP: a legacy from Carl Woese to microbiology. RNA Biol 11:239-43
Cole, James R; Wang, Qiong; Fish, Jordan A et al. (2014) Ribosomal Database Project: data and tools for high throughput rRNA analysis. Nucleic Acids Res 42:D633-42
Rhodes, Albert N; Fulthorpe, Roberta R; Tiedje, James M (2013) Probing the functional diversity of global pristine soil communities with 3-chlorobenzoate reveals that communities of generalists dominate catabolic transformation. Appl Environ Microbiol 79:6932-40
Forgacs, Agnes L; Dere, Edward; Angrish, Michelle M et al. (2013) Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes. Toxicol Sci 133:54-66
Kopec, Anna K; Boverhof, Darrell R; Nault, Rance et al. (2013) Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 135:465-75
Zhang, Qiang; Kline, Douglas E; Bhattacharya, Sudin et al. (2013) All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 268:17-26
Fullerton, Aaron M; Roth, Robert A; Ganey, Patricia E (2013) 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicol Appl Pharmacol 266:317-27
Angrish, Michelle Manente; Dominici, Claudia Yvette; Zacharewski, Timothy Richard (2013) TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice. Toxicol Sci 131:108-15
Zhang, Qiang; Bhattacharya, Sudin; Andersen, Melvin E (2013) Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol 3:130031
Nault, Rance; Forgacs, Agnes L; Dere, Edward et al. (2013) Comparisons of differential gene expression elicited by TCDD, PCB126, *NF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicol Lett 223:52-9

Showing the most recent 10 out of 342 publications