Naturally occurring and anthropogenic pollutants adversely affect human and ecosystem health. Knowledge from biomedical research is not utilized to its maximum potential unless it is effectively communicated in an understandable manner to health professionals, government regulatory agencies, industry and other end users, or stakeholders. We hypothesize that effective bidirectional communication between research scientists and stakeholders of research findings will improve the research being conducted by scientists provide more relevant information for regulatory agencies, enhance the overall benefits of this research, and ultimately lead to the best possible solutions to existing environmental problems. The Michigan State University (MSU) Superfund Research Program (SRP) Center focuses on the toxicology and environmental fate of dioxin and dioxin-like compounds (DLC), which have been identified as environmental contaminants in the Tri-Cities (Saginaw, Midland, Bay City) area in Michigan. The MSU SRP Center Research Translation Core (RTC) will serve as a bidirectional bridge for disseminating information, technology transfer and educational activities between the MSU SRP Center and key stakeholders. Specifically, our stakeholders are State government agencies, including Michigan Department Environment Quality (MDEQ) and Michigan Department of Agriculture Michigan Department of Agriculture and Rural Development (MDARD), Federal government agencies, including the United States Environmental Protection Agency (USEPA) Region 5 and the Agency for Toxic Substances and Disease Registry (ATSDR), and industry, such as the Sediment Management Working Group (SMWG). Ultimately, the most important stakeholders are the residents in communities in which environmental contamination exists and therefore, we have identified health professionals in community-based hospitals as novel stakeholders since they can be critical conduits of research translation. Training of health professionals will occur at the Flint and Midland Regional Campuses of the MSU College of Human Medicine. This aforementioned consortium of stakeholders provides a unique opportunity for scientists from government, industry and academia to collaborate on solutions to complex environmental problems surrounding dioxin and DLC in the State of Michigan. Toward this end, the above stated hypothesis will be tested by: (a) using well-established communication tools;(b) partnering with government and industry;(c) transferring technology using novel mechanisms;and (d) providing educational resources.

Public Health Relevance

Knowledge from health-related research is not utilized to its maximum potential unless it is effectively communicated in an understandable manner to health professionals, government regulatory agencies, industry, the community, and other stakeholders. The Research Translation Core will facilitate the flow of information between basic-science being conducted by the MSU SRP Center and key stakeholders to minimize the health hazards of dioxin and dioxin-like compounds to humans and the environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004911-23
Application #
8695361
Study Section
Special Emphasis Panel (ZES1-LWJ-D)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
23
Fiscal Year
2014
Total Cost
$178,431
Indirect Cost
$62,189
Name
Michigan State University
Department
Type
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Nault, Rance; Doskey, Claire M; Fader, Kelly A et al. (2018) Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol 94:876-884
Dornbos, Peter; LaPres, John J (2018) Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8
Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Interfacial Structure and Interaction of Kaolinite Intercalated with N-methylformamide Insight from Molecular Dynamics Modeling. Appl Clay Sci 158:204-210
Fader, Kelly A; Nault, Rance; Raehtz, Sandi et al. (2018) 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98
Zhang, Shuai; Liu, Qinfu; Cheng, Hongfei et al. (2018) Mechanism Responsible for Intercalation of Dimethyl Sulfoxide in Kaolinite: Molecular Dynamics Simulations. Appl Clay Sci 151:46-53
Zhang, Qiang; Li, Jin; Middleton, Alistair et al. (2018) Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. Front Public Health 6:261
Fader, K A; Nault, R; Kirby, M P et al. (2018) Corrigendum to ""Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERB?/? activation in aryl hydrocarbon receptor-elicited hepatotoxicity"" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17]. Toxicol Appl Pharmacol 344:74
Konganti, Kranti; Ehrlich, Andre; Rusyn, Ivan et al. (2018) gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3 (Bethesda) 8:2559-2562
Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Molecular Dynamics Simulation of Basal Spacing, Energetics, and Structure Evolution of a Kaolinite-Formamide Intercalation Complex and Their Interfacial Interaction. J Phys Chem C Nanomater Interfaces 122:3341-3349
Fader, Kelly A; Zacharewski, Timothy R (2017) Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds. Curr Opin Toxicol 2:36-41

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