The essence of the University of Arizona Superfund Basic Research Program (UA SBRP) renewal application is hazardous waste risk and remediation In the US Southwest. The theme of this Program Is to support development of a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and innovative remediation technologies. Our application emphasizes hazardous waste issues in the Southwest (and Mexican Border) associated with the distinctive arid nature of the environment. Importantly, the outcomes of these studies can be extrapolated to arid environments around the world. Currently 1/3 of land surfaces are arid or semi arid and this proportion is expected to increase due to climate change. This is exemplified by the toxicants we study, metals (arsenic) and halogenated hydrocarbons, which are major contaminants in our region but also of significant concern throughout the world. Our Program consists of 9 research projects - five biomedical projects and four environmental sciences projects. Many of the projects are collaborative involving multiple disciplines. The biomedical projects are examining the mechanism of arsenic toxicity in target tissues, factors that affect the susceptibility of populations to arsenic-induced toxicity, and potential therapeutic approaches. The environmental sciences projects are investigating how hazardous wastes (arsenic, TCE/PCE) can be optimally characterized for risk assessment and remediation, and developing innovative techniques for assessing exposure and waste containment in our arid Southwest environment. These research projects are supported by five Cores that: administer the Program, translate the results to stakeholders, provide research services, promote unique outreach efforts to ethnic communities along the Border, and support graduate student training. This project will contribute to our understanding of toxicology and remediation of hazardous wastes nationally and internationally.

Public Health Relevance

This application emphasizes hazardous waste issues in the Southwest associated with the distinctive arid nature of the environment. Water is precious in arid environments and dust is ever present. Contamination of our water or soil by hazardous waste affects broad populations. We must assess the health risks, containment, and remediation of ubiquitous contaminants [metals (arsenic) and halogenated solvents] present in the arid Southwest and use this information for handling these contaminants at other sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES004940-25S1
Application #
8884024
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Carlin, Danielle J
Project Start
1997-04-01
Project End
2015-03-31
Budget Start
2014-07-01
Budget End
2015-03-31
Support Year
25
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Arizona
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Khan, Muhammad Amjad; Ding, Xiaodong; Khan, Sardar et al. (2018) The influence of various organic amendments on the bioavailability and plant uptake of cadmium present in mine-degraded soil. Sci Total Environ 636:810-817
Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38
Fu, Xiaori; Dionysiou, Dionysios D; Brusseau, Mark L et al. (2018) Enhanced effect of EDDS and hydroxylamine on Fe(II)-catalyzed SPC system for trichloroethylene degradation. Environ Sci Pollut Res Int 25:15733-15742
Duncan, Candice M; Brusseau, Mark L (2018) An assessment of correlations between chlorinated VOC concentrations in tree tissue and groundwater for phytoscreening applications. Sci Total Environ 616-617:875-880
Virgone, K M; Ramirez-Andreotta, M; Mainhagu, J et al. (2018) Effective integrated frameworks for assessing mining sustainability. Environ Geochem Health 40:2635-2655
Namdari, Soodabeh; Karimi, Neamat; Sorooshian, Armin et al. (2018) Impacts of climate and synoptic fluctuations on dust storm activity over the Middle East. Atmos Environ (1994) 173:265-276
Hossein Mardi, Ali; Khaghani, Ali; MacDonald, Alexander B et al. (2018) The Lake Urmia environmental disaster in Iran: A look at aerosol pollution. Sci Total Environ 633:42-49
Dehghani, Mansooreh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of BTEX in a hot spot for urban pollution. Ecotoxicol Environ Saf 155:133-143
Pu, Mengjie; Guan, Zeyu; Ma, Yongwen et al. (2018) Synthesis of iron-based metal-organic framework MIL-53 as an efficient catalyst to activate persulfate for the degradation of Orange G in aqueous solution. Appl Catal A Gen 549:82-92
Brusseau, Mark L; Guo, Zhilin (2018) The integrated contaminant elution and tracer test toolkit, ICET3, for improved characterization of mass transfer, attenuation, and mass removal. J Contam Hydrol 208:17-26

Showing the most recent 10 out of 497 publications