Abstract

This application, prepared in response to RFA ES-91-02, will address the need for additional studies on neurological and behavioral aspects of chemicals commonly found in Superfund dumpsites. Research focus within the eight multidisciplinary projects of the program will be achieved by addressing specifically the neurotoxicity of selected solvents (trichloroethylene, monochloroacetic acid, related halogenated hydrocarbons) and metals (lead). Projects have been designed to examine: 1. the hydrogeology of solvents. 2. the neurotoxicity of solvents at the biochemical/cellular levels. 3. the neurotoxicity of lead on developing and adult neuronal systems. 4. the ecological and human neurobehavioral responses to lead and solvents. 5. engineering approaches to the biological treatment of Superfund contaminants. These studies will be conducted by members of the Environmental and Occupational Health Sciences Institute, a research institute comprising investigators from Rutgers, The State University of New Jersey and R.W. Johnson Medical School, The University of Medicine and Dentistry of New Jersey.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
1P42ES005955-01
Application #
3104532
Study Section
Special Emphasis Panel (SRC (S1))
Project Start
1992-04-01
Project End
1995-03-30
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Rutgers University
Department
Type
Schools of Pharmacy
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901

  Publications

Caccappolo-van Vliet, Elise; Kelly-McNeil, Kathie; Natelson, Benjamin et al. (2002) Anxiety sensitivity and depression in multiple chemical sensitivities and asthma. J Occup Environ Med 44:890-901
Caccappolo, E; Kipen, H; Kelly-McNeil, K et al. (2000) Odor perception: multiple chemical sensitivities, chronic fatigue, and asthma. J Occup Environ Med 42:629-38
Pignatello, M A; Kauffman, F C; Levin, A A (1999) Multiple factors contribute to the toxicity of the aromatic retinoid TTNPB (Ro 13-7410): interactions with the retinoic acid receptors. Toxicol Appl Pharmacol 159:109-16
Burger, J (1997) The historical basis for ecological risk assessment. Ann N Y Acad Sci 837:360-71
Dey, P M; Polunas, M A; Philbert, M A et al. (1997) Altered expression of polysialylated NCAM in mouse hippocampus following trimethyltin administration. Neurotoxicology 18:633-43
Burger, J; Gochfeld, M (1997) Heavy metal and selenium concentrations in feathers of egrets from Bali and Sulawesi, Indonesia. Arch Environ Contam Toxicol 32:217-21
Burger, J; Gochfeld, M (1997) Lead and neurobehavioral development in gulls: a model for understanding effects in the laboratory and the field. Neurotoxicology 18:495-506
Burger, J; Shukla, T; Benson, T et al. (1997) Lead levels in exposed herring gulls: differences in the field and laboratory. Toxicol Ind Health 13:193-202
Burger, J; Gochfeld, M (1997) Paradigms for ecological risk assessment. Ann N Y Acad Sci 837:372-86
Pignatello, M A; Kauffman, F C; Levin, A A (1997) Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol 142:319-27

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