The overall objective of this Superfund Basic Research Program Project on toxic metals is to understand the human health impact of exposure to arsenic and mercury from environmental and anthropogenic sources. This program consists of three biomedical and two non-biomedical research projects, two scientific support cores, and an Administrative, Research Translation and Training Core. Projects 2 (Hamilton) and 8 (Stanton) are molecular toxicology projects investigating the molecular mechanisms by which arsenic elicits its adverse health effects, focusing on endocrine disruption and disruption of membrane protein trafficking and function, respectively. Project 7 (Chen) is an ecotoxicology project examining how mercury bioaccumulates in fish, and Project 9 is a plant biology project focusing on bioaccumulation of arsenic in rice, each focusing on how these lead to human exposures of concern. Project 4 (Karagas) is examining the human health effects of exposure to arsenic and mercury, focusing on reproductive and developmental effects in offspring of pregnant women in New Hampshire who are exposed to these toxicants via their food (arsenic and mercury) and well water (arsenic). Core B (Jackson) is a Trace Elements Analysis Core that provides state-of-the-art ultra-low level detection, quantitation and speciation of arsenic and mercury. Core E (Moore) is an Integrative Biology Core that provides comprehensive support and integration of knowledge from the project-specific molecular biology, genomics, proteomics, bioinformatics, biostatistics and modeling analysis (each provided by individual cores at Dartmouth) to the program in order to more fully understand, integrate and translate this knowledge to stakeholders. The investigators'Research Translation Core is designed to effectively facilitate this translation by assisting them in communicating the proper information in the most effective and appropriate way to each stakeholder group. The Training Core is designed to exploit their highly interdisciplinary and collaborative program in order to foster the most effective training of their students. The goal is to provide the very best science that can be used for more effective science-based risk assessments, for predicting the specific patho-physiological consequences of arsenic and mercury exposure, for assessing gene-environment, agent-agent and other complex environmental interactions, for assessing specifically sensitive sub-populations at elevated risk, and for developing effective interventions for these exposed populations.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-JAB-C (S7))
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Carlin, Danielle J
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Dartmouth College
Schools of Medicine
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Jonsson, Sofi; Mazrui, Nashaat M; Mason, Robert P (2016) Dimethylmercury Formation Mediated by Inorganic and Organic Reduced Sulfur Surfaces. Sci Rep 6:27958
Goossens, Maria E; Isa, Fatima; Brinkman, Maree et al. (2016) International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics. Arch Public Health 74:30
Kwon, Sae Yun; Blum, Joel D; Chen, Celia Y et al. (2016) Correction to Mercury Isotope Study of Sources and Exposure Pathways of Methylmercury in Estuarine Food Webs in the Northeastern U.S. Environ Sci Technol 50:3283
Lee, Cheng-Shiuan; Lutcavage, Molly E; Chandler, Emily et al. (2016) Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environ Sci Technol 50:12825-12830
Taylor, Vivien; Goodale, Britton; Raab, Andrea et al. (2016) Human exposure to organic arsenic species from seafood. Sci Total Environ :
Gribble, Matthew O; Karimi, Roxanne; Feingold, Beth J et al. (2016) Mercury, selenium and fish oils in marine food webs and implications for human health. J Mar Biol Assoc U.K. 96:43-59
Taylor, Vivien F; Jackson, Brian P (2016) Concentrations and speciation of arsenic in New England seaweed species harvested for food and agriculture. Chemosphere 163:6-13
Karimi, Roxanne; Chen, Celia Y; Folt, Carol L (2016) Comparing nearshore benthic and pelagic prey as mercury sources to lake fish: the importance of prey quality and mercury content. Sci Total Environ 565:211-21
Gilbert-Diamond, Diane; Emond, Jennifer A; Baker, Emily R et al. (2016) Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire. Environ Health Perspect 124:1299-307
Farzan, Shohreh F; Gossai, Anala; Chen, Yu et al. (2016) Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study. Environ Health 15:106

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