The primary goal of the Trace Element Analysis (TEA) Core (Core B) is to provide specific analytical services and analytical expertise to Dartmouth SBRP researchers to allow them to successfully complete the aims of their individual projects. Additionally, the TEA Core strives to be at the forefront of (mission-related) method development that augments the themes of the Dartmouth SBRP projects and advances these projects by providing analytical advances such as lower detection limits, quantification of an as yet unmeasured metal species, or the novel application of an analytical methodology. The TEA Core utilizes state of the art analytical instrumentation based on inductively coupled plasma mass spectrometry (ICP-MS) to provide low level determinations of trace elements in a variety of biological and environmental matrices. The TEA Core also provides speciation analysis for arsenic and mercury by liquid chromatography and gas chromatography coupled to ICP-MS, respectively. The chemical form (species) of arsenic or mercury in a sample ultimately determines the toxicity of that element, hence speciation information is essential in assessing the human health effects of these ubiquitous contaminant elements. The TEA Core provides toenail and hair analysis to assess the exposure of an individual to trace metals. Methods have been developed to quantify six chemical species of arsenic in human urine;these species range from arsenobetaine, a non-toxic form of arsenic that people are routinely exposed to through seafood, to monomethlarsenous acid, MMA(III), an extremely toxic chemical form of arsenic. The TEA Core also provides methodology to speciate mercury at extremely low levels and in very small sample masses. Our GC-ICP-MS methods can detect less than 1 picogram of mercury and can determine mercury species in sub milligram sample weights. Methylmercury is an extremely toxic form of mercury that bioaccumulates through the food chain, hence it is essential to be able to determine this mercury species at very low levels. The TEA Core continues to push the boundary of low level trace element detection to develop and validate methods for the determination of trace elements or elemental species in biological samples with the goal of providing Dartmouth SRBP researchers the information they need to make better predictive decisions about human and ecosystem health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007373-18
Application #
8376742
Study Section
Special Emphasis Panel (ZES1-JAB-C)
Project Start
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
18
Fiscal Year
2012
Total Cost
$147,004
Indirect Cost
$57,557
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Jonsson, Sofi; Mazrui, Nashaat M; Mason, Robert P (2016) Dimethylmercury Formation Mediated by Inorganic and Organic Reduced Sulfur Surfaces. Sci Rep 6:27958
Goossens, Maria E; Isa, Fatima; Brinkman, Maree et al. (2016) International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics. Arch Public Health 74:30
Kwon, Sae Yun; Blum, Joel D; Chen, Celia Y et al. (2016) Correction to Mercury Isotope Study of Sources and Exposure Pathways of Methylmercury in Estuarine Food Webs in the Northeastern U.S. Environ Sci Technol 50:3283
Lee, Cheng-Shiuan; Lutcavage, Molly E; Chandler, Emily et al. (2016) Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environ Sci Technol 50:12825-12830
Taylor, Vivien; Goodale, Britton; Raab, Andrea et al. (2016) Human exposure to organic arsenic species from seafood. Sci Total Environ :
Gribble, Matthew O; Karimi, Roxanne; Feingold, Beth J et al. (2016) Mercury, selenium and fish oils in marine food webs and implications for human health. J Mar Biol Assoc U.K. 96:43-59
Taylor, Vivien F; Jackson, Brian P (2016) Concentrations and speciation of arsenic in New England seaweed species harvested for food and agriculture. Chemosphere 163:6-13
Karimi, Roxanne; Chen, Celia Y; Folt, Carol L (2016) Comparing nearshore benthic and pelagic prey as mercury sources to lake fish: the importance of prey quality and mercury content. Sci Total Environ 565:211-21
Gilbert-Diamond, Diane; Emond, Jennifer A; Baker, Emily R et al. (2016) Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire. Environ Health Perspect 124:1299-307
Farzan, Shohreh F; Gossai, Anala; Chen, Yu et al. (2016) Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study. Environ Health 15:106

Showing the most recent 10 out of 308 publications