Research Translation Core: Abstract The scientific goals of the Dartmouth Superfund Research Program (SRP) are to investigate the effects on human health of low, environmentally relevant levels of arsenic and mercury, two of the top three toxicants on the ATSDR National Priority List of Hazardous Substances. Over the last 18 years, our Program has been committed to producing and communicating knowledge that informs science-based decision-making with regard to risks from human exposure to these contaminants. The Research Translation Core has utilized novel and effective approaches to facilitate the understanding and application of our research by our stakeholders and end-users. In our proposed Program, our efforts will be directed toward three significant audiences: Government Partners and Policymakers;Communities Affected by Exposures to Arsenic and Mercury;and Scientific and Health Care Professionals. Research translation methods used to accomplish the new specific aims listed below will include, partnering with government agencies, collaborative workshops, community feedback on risk perceptions, web-based communication, and media training.
Aim 1. Assist U.S. EPA Region I in communicating risk assessment and remediation at two Superfund sites containing metal contaminants in Berlin, NH and Brooksville, ME;
Aim 2. Share innovative methods focused on low-level detection, speciation, and imaging of metals;
Aim 3. Facilitate dialogue between scientists and policymakers to address knowledge gaps and advance the science concerning the sources and effects of arsenic exposure;
Aim 4. Collaborate with ATSDR, EPA, and the New England Pediatric Environmental Health Specialty Unit to help target audiences make risk-based decisions relating to arsenic in food and mercury in fish;
Aim 5. Train our researchers and trainees to communicate their research and develop relationships with stakeholders and end-users;
Aim 6. Develop a centralized web-based information source for the public and other stakeholders to obtain and share information on sources, exposures and effects of arsenic and mercury.

Public Health Relevance

Research Translation Core: Narrative The Research Translation Core ensures that the Center's research accomplishments are appropriately communicated to our stakeholders and end-users to advance the understanding and application of our arsenic and mercury science for the protection of public health. Our research has specific relevance to the development of policies and regulations on human and environmental exposures to arsenic and mercury at regional, national and global scales.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES007373-19A1
Application #
8650444
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
City
Hanover
State
NH
Country
United States
Zip Code
03755
Chu, Heng-Hsuan; Car, Suzana; Socha, Amanda L et al. (2017) The Arabidopsis MTP8 transporter determines the localization of manganese and iron in seeds. Sci Rep 7:11024
Baumann, Zofia; Mason, Robert P; Conover, David O et al. (2017) Mercury bioaccumulation increases with latitude in a coastal marine fish (Atlantic silverside, Menidia menidia). Can J Fish Aquat Sci 74:1009-1015
Lee, Cheng-Shiuan; Fisher, Nicholas S (2017) Bioaccumulation of methylmercury in a marine copepod. Environ Toxicol Chem 36:1287-1293
Taylor, Vivien F; Li, Zhigang; Sayarath, Vicki et al. (2017) Distinct arsenic metabolites following seaweed consumption in humans. Sci Rep 7:3920
Goodale, Britton C; Rayack, Erica J; Stanton, Bruce A (2017) Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol 331:154-163
Punshon, Tracy; Jackson, Brian P; Meharg, Andrew A et al. (2017) Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants. Sci Total Environ 581-582:209-220
Farzan, Shohreh F; Brickley, Elizabeth B; Li, Zhigang et al. (2017) Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort. Environ Res 156:426-433
Cubadda, Francesco; Jackson, Brian P; Cottingham, Kathryn L et al. (2017) Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties. Sci Total Environ 579:1228-1239
Davis, Matthew A; Signes-Pastor, Antonio J; Argos, Maria et al. (2017) Assessment of human dietary exposure to arsenic through rice. Sci Total Environ 586:1237-1244
Martin, Elizabeth; Smeester, Lisa; Bommarito, Paige A et al. (2017) Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period. Epigenomics 9:267-278

Showing the most recent 10 out of 335 publications