The University of Kentucky is unique among land grant universities in that all colleges, including Medicine and Agriculture, are located on the same campus. This constellation of programs has enabled the UK-SBRP to develop uniquely productive collaborations across diverse disciplines. Such an environment will allow to study the overall theme of the SBRP research, which focuses on the toxicology of Superfund chemicals and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition, respectively. Given the abundance of Superfund chemicals and widespread distribution in the ecosystem, it is unlikely that remediation alone will be sufficient to address their health risks. Nutritional intervention thus becomes a sensible way to address health problems associated with environmental pollutants. In the competing renewal, the investigators recognize this dual need for sensing/remediation and biomedical intervention through nutrition by proposing five integrated projects. The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky. Preliminary findings by this group suggest that nutrition and dietary habits can markedly influence mechanisms of toxicity of the above-mentioned Superfund chemicals. Thus, a major objective of our SBRP is to explore the paradigm that nutrition can modify Superfund chemical toxicity. All biomedical projects will focus on chronic diseases associated with vascular dysfunction, such as cardiovascular disease, cancer metastasis, and obesity-related abdominal aortic aneurysms, and will utilize a similar dietary fat regimen to study nutrient/toxicant interactions. There will be significant cross-talk with non-biomedical projects, which will explore novel techniques for both remediation (detoxification) and biosensors associated with detection of PCBs and other chlorinated organics. Results from interdisciplinary research will be utilized for information/education, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. Nutrition may be the most sensible means to develop primary prevention strategies of diseases associated with many environmental toxic insults. Thus, research proposed by the investigators may lead to novel dietary recommendations at the national level for populations at risk, thus improving the health of people residing near Superfund sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007380-16
Application #
8249969
Study Section
Special Emphasis Panel (ZES1-JAB-C (S7))
Program Officer
Henry, Heather F
Project Start
1997-04-07
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
16
Fiscal Year
2012
Total Cost
$2,094,986
Indirect Cost
$803,902
Name
University of Kentucky
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Hoffman, Jessie B; Hennig, Bernhard (2017) Protective influence of healthful nutrition on mechanisms of environmental pollutant toxicity and disease risks. Ann N Y Acad Sci 1398:99-107
Tang, Shuo; Floy, Martha; Bhandari, Rohit et al. (2017) Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4'-Dihydroxybiphenyl Diacrylate. ACS Omega 2:8723-8729
Reichman, Rivka; Shirazi, Elham; Colliver, Donald G et al. (2017) US residential building air exchange rates: new perspectives to improve decision making at vapor intrusion sites. Environ Sci Process Impacts 19:87-100
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Hennig, Bernhard (2017) Environmental challenges in Central and Eastern Europe. Rev Environ Health 32:1
Perkins, Jordan T; Petriello, Michael C; Xu, Li et al. (2017) An open-sourced statistical application for identifying complex toxicological interactions of environmental pollutants. Rev Environ Health 32:23-26
Shirazi, Elham; Pennell, Kelly G (2017) Three-dimensional vapor intrusion modeling approach that combines wind and stack effects on indoor, atmospheric, and subsurface domains. Environ Sci Process Impacts 19:1594-1607
Bertrand, Luc; Dygert, Levi; Toborek, Michal (2017) Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area. J Vis Exp :
Gutierrez, Angela M; Dziubla, Thomas D; Hilt, J Zach (2017) Recent advances on iron oxide magnetic nanoparticles as sorbents of organic pollutants in water and wastewater treatment. Rev Environ Health 32:111-117
Hoffman, Jessie B; Petriello, Michael C; Hennig, Bernhard (2017) Impact of nutrition on pollutant toxicity: an update with new insights into epigenetic regulation. Rev Environ Health 32:65-72

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