The Research Support Core (Core B) of the Superfund Basic Research Program at the University of Kentucky (UK-SBRP) will perform the vital role of supporting the research activities of all biomedical and non-biomedical projects. The main objective of Core B is to provide a central facility that will enhance and develop the research capabilities of the University of Kentucky SBRP (UK SBRP), particularly in the areas of systems biology, bioinformatics/biostatistics, proteomics, and PCB analysis. Creation of a central facility in these research areas is critical to study the impact of nutrition on the toxicity of environmental pollutants (primarily PCBs). Establishment of a coordinated effort in the form of one Research Support Core will maximize both the research and cost effectiveness of UKSBRP. Core B consists of four entities (namely, Systems Biology, Bioinformatics/Biostatistical Analysis, Proteomics, and Analytical Components) directed by an expert in each area.
The Aims of Core B are: 1. Cross-link the individual research projects by developing a unified data management infrastructure and by providing feedback information to guide the process of discovering common pathways and mechanisms of modulatory effects of diets on vascular pathology of PCBs. 2 Integrate diverse biological data from the individual research projects in order to generate a comprehensive systems biology model of the effects of nutrition on PCB-induced vascular toxicity. 3. Develop and provide analytical services, expertise, and technical support in the areas of bioinformatics, proteomics, and PCB analysis. 4. Provide training and support on using bioinformatics and systems biology tools as well as analytical chemistry approaches for toxicology research to all investigators involved in the UK-SBRP. Core B will bind together critical research activities of individual projects to enhance the overall research potential and success of UK-SBRP. Thus, it will not only offer research services but will also be critical for integration of individual research projects into a unified entity. In addition to providing a uniform platform for generation and computational analysis of high-throughput data (microarrays and proteomics), the Core will employ the systems biology approaches to create predictive models to better anticipate the effects of nutrition on toxicity of superfund chemicals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007380-16
Application #
8377270
Study Section
Special Emphasis Panel (ZES1-JAB-C)
Project Start
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
16
Fiscal Year
2012
Total Cost
$265,927
Indirect Cost
$89,322
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Murphy, Margaret O; Petriello, Michael C; Han, Sung Gu et al. (2016) Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci Pollut Res Int 23:2201-11
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Platt, Kristen M; Charnigo, Richard J; Shertzer, Howard G et al. (2016) Branched-Chain Amino Acid Supplementation in Combination with Voluntary Running Improves Body Composition in Female C57BL/6 Mice. J Diet Suppl 13:473-86
Wahlang, Banrida; Petriello, Michael C; Perkins, Jordan T et al. (2016) Polychlorinated biphenyl exposure alters the expression profile of microRNAs associated with vascular diseases. Toxicol In Vitro 35:180-7
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Liu, Dandan; Perkins, Jordan T; Hennig, Bernhard (2016) EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells. J Nutr Biochem 28:164-70
Kania-Korwel, Izabela; Lehmler, Hans-Joachim (2016) Chiral polychlorinated biphenyls: absorption, metabolism and excretion-a review. Environ Sci Pollut Res Int 23:2042-57
Petriello, Michael C; Hoffman, Jessie B; Sunkara, Manjula et al. (2016) Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors. J Nutr Biochem 33:145-53
Baker, Nicki A; Shoemaker, Robin; English, Victoria et al. (2015) Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice. Environ Health Perspect 123:944-50

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