The environmental challenge posed by Superfund chemicals is of high magnitude and affects several aspects of human life.
The aim of the University of Kentucky Superfund Program is studying the effects of nutrition on the toxicity of Superfund chemicals, detection of these chemicals and their remediation. To solve any environmental problems, the emerging researchers should have specific scientific training, broad knowledge of different disciplines and be effective communicators. The Training Core plans to address this need through cross-disciplinary graduate education and a training program in environmental sciences. The collaboration of the Training Core with the individual projects and the other Cores of the UK-SBRP will expose our trainees to both basic and applied research. In addition to their involvement in individual projects, trainees will be introduced to (a) proteomics, EPA methods, and Bioinformatics and Systems Biology in Toxicology though workshops organized by the Research Support Core (Core B);(b) Research Translation strategies through workshops and participation in the activities of the Research Translation Core (Core C);and (c) real environmental problems through participation in the activities of the Community Outreach Core in communities residing close to Superfund sites. The goals of the Training Core are (i) to provide thorough training of students in their specific field, (ii) to instill basic knowledge about socioeconomic, law, engineering and science aspects, (iii) to enhance the ability of students to communicate with scientists as well as non-scientists. In addition to providing student stipents, the Training Core will make available travel funds to student trainees and postdoctoral scholars to present their Superfund-related research at scientific conferences. Emphasis will be placed on identifying and recruiting motivated individuals and students from underrepresented groups through brochures, web page, and presentations at minority institutions. The Training Core program will be evaluated on a regular basis to assess the progress in meeting the goals of the program. This will be accomplished by, first, evaluating the progress of the trainees toward their educational goals, and second, in terms of how the trainees view and value the program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007380-16
Application #
8377273
Study Section
Special Emphasis Panel (ZES1-JAB-C)
Project Start
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
16
Fiscal Year
2012
Total Cost
$171,815
Indirect Cost
$89,321
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Murphy, Margaret O; Petriello, Michael C; Han, Sung Gu et al. (2016) Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci Pollut Res Int 23:2201-11
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Liu, Dandan; Perkins, Jordan T; Hennig, Bernhard (2016) EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells. J Nutr Biochem 28:164-70
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Petriello, Michael C; Hoffman, Jessie B; Sunkara, Manjula et al. (2016) Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors. J Nutr Biochem 33:145-53
Baker, Nicki A; Shoemaker, Robin; English, Victoria et al. (2015) Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice. Environ Health Perspect 123:944-50

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