(Administrative Core - Hennig, Ormsbee, Hoover) The overarching goal of the University of Kentucky Superfund Research Center (UK-SRC) is to reduce risk from exposure to environmentally persistent chlorinated organics, which are prevalent at Superfund sites, using polychlorinated biphenyls (PCBs) as a model pollutant. The UK-SRC proposes to address this goal through an integrated program of biomedical and environmental science research focused on pro-inflammatory health impacts of PCBs and innovations in environmental remediation technology. Further, the Center uses the combined understandings from these two complementary areas of study to explore positive lifestyle practices (e.g., nutrition-based approaches) to modulate health effects as well as environmentally benign nano-based approaches to mitigate the environmental threat. To achieve these goals, the Administrative Core provides high level coordination of transdisciplinary scientific interactions across biomedical and environmental science domains, associated interdisciplinary research training and multi-directional translation efforts across diverse sectors-federal government, state agencies, the private sector and other stakeholders at community and individual levels. To provide an optimal support environment and the requisite infrastructure to accomplish the Center's goal, we propose four specific aims to: 1) implement high level planning and coordination of research activities by implementing effective leadership, identifying emerging research, facilitating complementary approaches and establishing processes for dissemination, translation and engagement;2) integrate diverse cross-disciplinary areas of research by promoting intra- and extra-Center communication and fostering collaboration and cooperation across projects and cores;3) provide effective fiscal management processes and oversight of core resources;4) facilitate high quality management processes that promote continuing research productivity, effective mentoring, accurate documentation/reporting and capacity to meet future challenges. The focus of the Administrative Core on the establishment and maintenance of iterative program development processes, along with multidirectional internal and external relationships, positions our Center to contribute not only important scientific findings but also collaborative processes, stakeholder-derived information and innovative endeavors to the national Superfund Research Program.

Public Health Relevance

(Administrative Core - Hennig, Ormsbee, Hoover) The Administrative Core of the University of Kentucky Superfund Research Program will continue to promote a set of approaches that apply principles of team science and rely on perspectives from different biomedical and environmental science disciplines. These approaches will address the problem of environmental contamination from a class of pollutants known as chlorinated organics. The goal will be to reduce risk from exposure to these compounds by studying their health effects and potential technical solutions in the environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES007380-17A1
Application #
8649933
Study Section
Special Emphasis Panel (ZES1-LKB-K (S))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
17
Fiscal Year
2014
Total Cost
$141,122
Indirect Cost
$40,320
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Murphy, Margaret O; Petriello, Michael C; Han, Sung Gu et al. (2016) Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci Pollut Res Int 23:2201-11
Perkins, Jordan T; Petriello, Michael C; Newsome, Bradley J et al. (2016) Polychlorinated biphenyls and links to cardiovascular disease. Environ Sci Pollut Res Int 23:2160-72
Platt, Kristen M; Charnigo, Richard J; Shertzer, Howard G et al. (2016) Branched-Chain Amino Acid Supplementation in Combination with Voluntary Running Improves Body Composition in Female C57BL/6 Mice. J Diet Suppl 13:473-86
Wahlang, Banrida; Petriello, Michael C; Perkins, Jordan T et al. (2016) Polychlorinated biphenyl exposure alters the expression profile of microRNAs associated with vascular diseases. Toxicol In Vitro 35:180-7
Pennell, Kelly G; Scammell, Madeleine K; McClean, Michael D et al. (2016) Field data and numerical modeling: A multiple lines of evidence approach for assessing vapor intrusion exposure risks. Sci Total Environ 556:291-301
Hunt, Gary; Stegeman, John; Robertson, Larry (2016) PCBs: exposures, effects, remediation, and regulation with special emphasis on PCBs in schools. Environ Sci Pollut Res Int 23:1971-4
Liu, Dandan; Perkins, Jordan T; Hennig, Bernhard (2016) EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells. J Nutr Biochem 28:164-70
Kania-Korwel, Izabela; Lehmler, Hans-Joachim (2016) Chiral polychlorinated biphenyls: absorption, metabolism and excretion-a review. Environ Sci Pollut Res Int 23:2042-57
Petriello, Michael C; Hoffman, Jessie B; Sunkara, Manjula et al. (2016) Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors. J Nutr Biochem 33:145-53
Baker, Nicki A; Shoemaker, Robin; English, Victoria et al. (2015) Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice. Environ Health Perspect 123:944-50

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