(Administrative Core - Hennig, Ormsbee, Hoover) The overarching goal of the University of Kentucky Superfund Research Center (UK-SRC) is to reduce risk from exposure to environmentally persistent chlorinated organics, which are prevalent at Superfund sites, using polychlorinated biphenyls (PCBs) as a model pollutant. The UK-SRC proposes to address this goal through an integrated program of biomedical and environmental science research focused on pro-inflammatory health impacts of PCBs and innovations in environmental remediation technology. Further, the Center uses the combined understandings from these two complementary areas of study to explore positive lifestyle practices (e.g., nutrition-based approaches) to modulate health effects as well as environmentally benign nano-based approaches to mitigate the environmental threat. To achieve these goals, the Administrative Core provides high level coordination of transdisciplinary scientific interactions across biomedical and environmental science domains, associated interdisciplinary research training and multi-directional translation efforts across diverse sectors-federal government, state agencies, the private sector and other stakeholders at community and individual levels. To provide an optimal support environment and the requisite infrastructure to accomplish the Center's goal, we propose four specific aims to: 1) implement high level planning and coordination of research activities by implementing effective leadership, identifying emerging research, facilitating complementary approaches and establishing processes for dissemination, translation and engagement;2) integrate diverse cross-disciplinary areas of research by promoting intra- and extra-Center communication and fostering collaboration and cooperation across projects and cores;3) provide effective fiscal management processes and oversight of core resources;4) facilitate high quality management processes that promote continuing research productivity, effective mentoring, accurate documentation/reporting and capacity to meet future challenges. The focus of the Administrative Core on the establishment and maintenance of iterative program development processes, along with multidirectional internal and external relationships, positions our Center to contribute not only important scientific findings but also collaborative processes, stakeholder-derived information and innovative endeavors to the national Superfund Research Program.

Public Health Relevance

(Administrative Core - Hennig, Ormsbee, Hoover) The Administrative Core of the University of Kentucky Superfund Research Program will continue to promote a set of approaches that apply principles of team science and rely on perspectives from different biomedical and environmental science disciplines. These approaches will address the problem of environmental contamination from a class of pollutants known as chlorinated organics. The goal will be to reduce risk from exposure to these compounds by studying their health effects and potential technical solutions in the environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES007380-17A1
Application #
8649933
Study Section
Special Emphasis Panel (ZES1-LKB-K (S))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
17
Fiscal Year
2014
Total Cost
$141,122
Indirect Cost
$40,320
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Hofe, Carolyn R; Feng, Limin; Zephyr, Dominique et al. (2014) Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004. Nutr Res 34:285-93
Xiao, Li; Isner, Austin; Waldrop, Krysta et al. (2014) Development of Bench and Full-Scale Temperature and pH Responsive Functionalized PVDF Membranes with Tunable Properties. J Memb Sci 457:39-49
Narbonne, Jean-François; Robertson, Larry W (2014) 7th International PCB Workshop: Chemical mixtures in a complex world. Environ Sci Pollut Res Int 21:6269-75
Petriello, Michael C; Newsome, Bradley J; Dziubla, Thomas D et al. (2014) Modulation of persistent organic pollutant toxicity through nutritional intervention: emerging opportunities in biomedicine and environmental remediation. Sci Total Environ 491-492:11-6
Newsome, Bradley J; Petriello, Michael C; Han, Sung Gu et al. (2014) Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes. J Nutr Biochem 25:126-35
Eske, Katryn; Newsome, Bradley; Han, Sung Gu et al. (2014) PCB 77 dechlorination products modulate pro-inflammatory events in vascular endothelial cells. Environ Sci Pollut Res Int 21:6354-64
Petriello, Michael C; Han, Sung Gu; Newsome, Bradley J et al. (2014) PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. Toxicol Appl Pharmacol 277:192-9
Równicka-Zubik, Joanna; Su?kowski, Leszek; Toborek, Michal (2014) Interactions of PCBs with human serum albumin: in vitro spectroscopic study. Spectrochim Acta A Mol Biomol Spectrosc 124:632-7
Hernández, Sebastián; Papp, Joseph K; Bhattacharyya, Dibakar (2014) Iron-Based Redox Polymerization of Acrylic Acid for Direct Synthesis of Hydrogel/Membranes, and Metal Nanoparticles for Water Treatment. Ind Eng Chem Res 53:1130-1142
Petriello, Michael C; Newsome, Bradley; Hennig, Bernhard (2014) Influence of nutrition in PCB-induced vascular inflammation. Environ Sci Pollut Res Int 21:6410-8

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