(Research Translation Core - Ormsbee, Gaetke, Hoover) To ensure optimal and effective translation of research outputs generated by the University of Kentucky Superfund Research Center (UK-SRC), the Research Translation Core (RTC) functions as the lead UK-SRC component responsible for external linkages and active communication with diverse relevant stakeholders. The UK-SRC addresses environmental health impacts of chlorinated organics, focusing on polychlorinated biphenyls (PCBs) and trichloroethylene (TCE). The Center's five research projects are integrated around the study of specific PCBs and positive lifestyle modifications (e.g., nutrition) to tackle the four national Superfund Research Program (SRP) mandates.
Specific aims explicitly address SRP program priorities. Thus, the RTC will 1) work with UK-SRC projects and cores to develop an integrated program that translates program- and project-specific outcomes to appropriate stakeholders, including NIEHS SRP staff and RTCs at other SRP centers nationally;translation mechanisms include electronic communication and participation in such SRP- wide activities as workshops, seminars, webinars, and the annual meeting;2) build on past successes to strengthen multidirectional agency partnerships, including the U.S. Environmental Protection Agency's Region 4 and National Risk Management Research Laboratory, Agency for Toxic Substances and Disease Registry, U.S. Department of Energy via the Paducah Gaseous Diffusion Plant (PGDP) National Priorities List site, the Kentucky Cabinet for Energy and the Environment, and the Kentucky Cabinet for Health and Family Services; 3) develop targeted research translation projects that leverage existing university resources, including the Center for Clinical and Translational Science, the Cooperative Extension Service, the Kentucky Water Resources Research Institute (an EPA-designated Center for Excellence for Watershed Management), the Kentucky Research Consortium for Energy and the Environment, the Public Health Practice-Based Research Network Program, and the Dissemination and Implementation Sciences Consortium. The RTC will also continue supporting UK-SRC project technology implementation at the PGDP;and 4) implement multidirectional strategies and best communication practices to disseminate program- and project-specific information to other end users. Communication channels include an interactive website, a risk management workshop, an expanded monthly seminar series, and targeted print and online materials related to specific research projects and emerging findings. The RTC will partner with UK resources and with other SRP RTCs to ensure broad-based information dissemination to relevant stakeholders. With the UK-SRC Community Engagement Core, the RTC will establish multidirectional relationships with two Superfund-impacted communities: 1) Dayhoit, Kentucky, in Appalachia, home to a Kentucky NPL site, and 2) Floyds Fork Watershed Community, a six-county area in central Kentucky, home to two NPL sites and near several others.

Public Health Relevance

(Research Translation Core - Ormsbee, Gaetke, Hoover) The Research Translation Core (RTC) uses multidirectional strategies and best communication practices to translate University of Kentucky Superfund Research Center research outcomes into decision-making, public policy, new technologies, practice innovations, and, ultimately, improvements in public health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Hofe, Carolyn R; Feng, Limin; Zephyr, Dominique et al. (2014) Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004. Nutr Res 34:285-93
Xiao, Li; Isner, Austin; Waldrop, Krysta et al. (2014) Development of Bench and Full-Scale Temperature and pH Responsive Functionalized PVDF Membranes with Tunable Properties. J Memb Sci 457:39-49
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Petriello, Michael C; Han, Sung Gu; Newsome, Bradley J et al. (2014) PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. Toxicol Appl Pharmacol 277:192-9
Równicka-Zubik, Joanna; Su?kowski, Leszek; Toborek, Michal (2014) Interactions of PCBs with human serum albumin: in vitro spectroscopic study. Spectrochim Acta A Mol Biomol Spectrosc 124:632-7
Hernández, Sebastián; Papp, Joseph K; Bhattacharyya, Dibakar (2014) Iron-Based Redox Polymerization of Acrylic Acid for Direct Synthesis of Hydrogel/Membranes, and Metal Nanoparticles for Water Treatment. Ind Eng Chem Res 53:1130-1142
Petriello, Michael C; Newsome, Bradley; Hennig, Bernhard (2014) Influence of nutrition in PCB-induced vascular inflammation. Environ Sci Pollut Res Int 21:6410-8

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