(Research Translation Core - Ormsbee, Gaetke, Hoover) To ensure optimal and effective translation of research outputs generated by the University of Kentucky Superfund Research Center (UK-SRC), the Research Translation Core (RTC) functions as the lead UK-SRC component responsible for external linkages and active communication with diverse relevant stakeholders. The UK-SRC addresses environmental health impacts of chlorinated organics, focusing on polychlorinated biphenyls (PCBs) and trichloroethylene (TCE). The Center's five research projects are integrated around the study of specific PCBs and positive lifestyle modifications (e.g., nutrition) to tackle the four national Superfund Research Program (SRP) mandates.
Specific aims explicitly address SRP program priorities. Thus, the RTC will 1) work with UK-SRC projects and cores to develop an integrated program that translates program- and project-specific outcomes to appropriate stakeholders, including NIEHS SRP staff and RTCs at other SRP centers nationally;translation mechanisms include electronic communication and participation in such SRP- wide activities as workshops, seminars, webinars, and the annual meeting;2) build on past successes to strengthen multidirectional agency partnerships, including the U.S. Environmental Protection Agency's Region 4 and National Risk Management Research Laboratory, Agency for Toxic Substances and Disease Registry, U.S. Department of Energy via the Paducah Gaseous Diffusion Plant (PGDP) National Priorities List site, the Kentucky Cabinet for Energy and the Environment, and the Kentucky Cabinet for Health and Family Services; 3) develop targeted research translation projects that leverage existing university resources, including the Center for Clinical and Translational Science, the Cooperative Extension Service, the Kentucky Water Resources Research Institute (an EPA-designated Center for Excellence for Watershed Management), the Kentucky Research Consortium for Energy and the Environment, the Public Health Practice-Based Research Network Program, and the Dissemination and Implementation Sciences Consortium. The RTC will also continue supporting UK-SRC project technology implementation at the PGDP;and 4) implement multidirectional strategies and best communication practices to disseminate program- and project-specific information to other end users. Communication channels include an interactive website, a risk management workshop, an expanded monthly seminar series, and targeted print and online materials related to specific research projects and emerging findings. The RTC will partner with UK resources and with other SRP RTCs to ensure broad-based information dissemination to relevant stakeholders. With the UK-SRC Community Engagement Core, the RTC will establish multidirectional relationships with two Superfund-impacted communities: 1) Dayhoit, Kentucky, in Appalachia, home to a Kentucky NPL site, and 2) Floyds Fork Watershed Community, a six-county area in central Kentucky, home to two NPL sites and near several others.

Public Health Relevance

(Research Translation Core - Ormsbee, Gaetke, Hoover) The Research Translation Core (RTC) uses multidirectional strategies and best communication practices to translate University of Kentucky Superfund Research Center research outcomes into decision-making, public policy, new technologies, practice innovations, and, ultimately, improvements in public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES007380-17A1
Application #
8649935
Study Section
Special Emphasis Panel (ZES1-LKB-K (S))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
17
Fiscal Year
2014
Total Cost
$132,300
Indirect Cost
$37,800
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Murphy, Margaret O; Petriello, Michael C; Han, Sung Gu et al. (2016) Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci Pollut Res Int 23:2201-11
Perkins, Jordan T; Petriello, Michael C; Newsome, Bradley J et al. (2016) Polychlorinated biphenyls and links to cardiovascular disease. Environ Sci Pollut Res Int 23:2160-72
Platt, Kristen M; Charnigo, Richard J; Shertzer, Howard G et al. (2016) Branched-Chain Amino Acid Supplementation in Combination with Voluntary Running Improves Body Composition in Female C57BL/6 Mice. J Diet Suppl 13:473-86
Wahlang, Banrida; Petriello, Michael C; Perkins, Jordan T et al. (2016) Polychlorinated biphenyl exposure alters the expression profile of microRNAs associated with vascular diseases. Toxicol In Vitro 35:180-7
Pennell, Kelly G; Scammell, Madeleine K; McClean, Michael D et al. (2016) Field data and numerical modeling: A multiple lines of evidence approach for assessing vapor intrusion exposure risks. Sci Total Environ 556:291-301
Hunt, Gary; Stegeman, John; Robertson, Larry (2016) PCBs: exposures, effects, remediation, and regulation with special emphasis on PCBs in schools. Environ Sci Pollut Res Int 23:1971-4
Liu, Dandan; Perkins, Jordan T; Hennig, Bernhard (2016) EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells. J Nutr Biochem 28:164-70
Kania-Korwel, Izabela; Lehmler, Hans-Joachim (2016) Chiral polychlorinated biphenyls: absorption, metabolism and excretion-a review. Environ Sci Pollut Res Int 23:2042-57
Petriello, Michael C; Hoffman, Jessie B; Sunkara, Manjula et al. (2016) Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors. J Nutr Biochem 33:145-53
Baker, Nicki A; Shoemaker, Robin; English, Victoria et al. (2015) Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice. Environ Health Perspect 123:944-50

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