The scientific theme for the Superfund Research Center at Boston University is receptor-based toxic effects of Superfund chemicals on development and reproduction in humans and wildlife. The chemicals under study are organic compounds of special interest to the SRP Center mandate that initiate their toxic actions by interacting with specific molecules inside cells called receptors. This interaction sets in motion chain of events that often leads to production of new proteins that alter the development of the cells. The research ranges from basic laboratory investigations to large scale epidemiologic studies of populations exposed through drinking water or around a Superfund site or molecular studies of fish ecology in a contaminated harbor. The object is to gain a better understanding of the implications of disturbances of reproductive and developmental processes, including aging, from exposures to hazardous substances in the environment. A special feature is a coordinated set of parallel projects examining molecular and population effects of developmental toxins in the standard laboratory zebra fish model and a widespread environmental sentinel, the killifish. Epidemiological studies of developmental outcomes from exposure to the high-prevalence Superfund chemicals perchloroethylene (PCE, tetrachloroethene), PCBs, the pesticide methoxychlor, phthalate, organotins and metals target knowledge gaps identified as special research needs by EPA/Agency for Toxic Substances and Disease Registry (ATSDR). A major feature is development of novel methods to address some of the most difficult problems associated with the typical hazardous waste epidemiological and toxicological datasets, temporal spatial distribution and interaction in mixtures. A Research Support Core provides expertise for highly sophisticated data analysis of Next Generation Sequencing and computer modeling of molecular structures, techniques used by five of the seven research projects. The Center includes two Core facilities dedicated to translating research for use in risk assessment by state and federal agencies and engaging the public and local health authorities in framing and shaping the scientific research agenda.

Public Health Relevance

US EPA and other regulatory agencies within the Federal system have a special interest in the possible reproductive and developmental effects of hazardous substances, including, but not limited to, those caused by endocrine disrupting agents. Despite increasingly sophisticated research, there is still much to learn about the seriousness of the problem.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-JAB-J (SF))
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Henry, Heather F
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Boston University
Public Health & Prev Medicine
Schools of Public Health
United States
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Carwile, Jenny L; Mahalingaiah, Shruthi; Winter, Michael R et al. (2014) Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study. Environ Health 13:72
Lowe, Margaret M; Mold, Jeff E; Kanwar, Bittoo et al. (2014) Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9:e87877
Hoffman, Kate; Vieira, Veronica M; Daniels, Julie L (2014) Brief report: diminishing geographic variability in autism spectrum disorders over time? J Autism Dev Disord 44:712-8
Parks, Ashley J; Pollastri, Michael P; Hahn, Mark E et al. (2014) In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86:593-608
Morrison, Ann Michelle Stanley; Goldstone, Jared V; Lamb, David C et al. (2014) Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14*-demethylase. Biochim Biophys Acta 1840:1825-36
Pillai, Hari K; Fang, Mingliang; Beglov, Dmitri et al. (2014) Ligand binding and activation of PPAR? by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122:1225-32
Reitzel, Adam M; Karchner, Sibel I; Franks, Diana G et al. (2014) Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol 14:6
Bristow, Robert E; Chang, Jenny; Ziogas, Argyrios et al. (2014) Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status. Gynecol Oncol 134:60-7
Quintana, Francisco J; Sherr, David H (2013) Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev 65:1148-61
Fraccalvieri, Domenico; Soshilov, Anatoly A; Karchner, Sibel I et al. (2013) Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52:714-25

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