This application proposes that the BU SRP Training Core will continue to provide interdisciplinary training in laboratory science, bioinformatics and computational biology, while also expanding the Training Core to act as a common reference point for all graduate students and post-doctoral fellows who work within the BU SRP program (including those who are supported by other BU SRP projects, other related training programs, and directly by the Training Core). The Training Core will directly support two students a year in bioinformatics techniques applied to the laboratory sciences, with an emphasis on analysis of high throughput, genome-wide data sets and on molecular modeling. This focus responds to the strategic importance of these methods for the biology of the future, the relative lack of exposure to them in traditional laboratory training programs, and the unique resources ofthe applicant institution. A major element ofthe program theme, the susceptibility ofthe developing organism to low-level xenobiotic exposures through a variety of pathways, is ideally suited to be the context for this cross discipline training. After nomination by project PIs at the end of their first year of study, two students will be selected by a Steering Committee consisting ofthe Program Director, the Training Core Director, and two additional BUSRP PIs, contingent on their commitment to one of the laboratories within the BUSRP. These students will receive appropriate core courses covering bioinformatics, reproduction and development, environmental health, and toxicology during their training program. In addition, we focus on communication skills, not only within the scientific community but to disseminate scientific knowledge to the broader community and to close the """"""""communication gap"""""""" between bench and laboratory science and the public at large. Importantly, the Training Core will orient graduate students and post-doctoral fellows supported by BU SRP projects or the Training Core to the mission, activities and needs of the NIEHS SRP, EPA and state environmental and health agencies;and thereby develop a sense of shared mission and peer network as they work towards advancing the science needed to provide a firm foundation for solving the complex health and environmental issues associated with the nation's hazardous waste sites.

Public Health Relevance

The program has direct relevance to public health due to the broad exposure of the public to many potentially toxic substances in everyday life. As the body of scientists trainined in the field increases, we can anticipate enhanced understanding ofthe potential danger posed by many of these substances and thus reduce the risk to the health ofthe general population

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-JAB-J)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
United States
Zip Code
Aschengrau, Ann; Janulewicz, Patricia A; White, Roberta F et al. (2016) Long-term Neurotoxic Effects of Early-life Exposure to Tetrachloroethylene-contaminated Drinking Water. Ann Glob Health 82:169-79
Mahalingaiah, S; Hart, J E; Laden, F et al. (2016) Adult air pollution exposure and risk of infertility in the Nurses' Health Study II. Hum Reprod 31:638-47
Hewlett, Meghan; Chow, Erika; Aschengrau, Ann et al. (2016) Prenatal Exposure to Endocrine Disruptors: A Developmental Etiology for Polycystic Ovary Syndrome. Reprod Sci :
Girguis, Mariam S; Strickland, Matthew J; Hu, Xuefei et al. (2016) Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environ Res 146:1-9
Reid, Noah M; Proestou, Dina A; Clark, Bryan W et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Science 354:1305-1308
Mahalingaiah, Shruthi; Winter, Michael R; Aschengrau, Ann (2016) Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study. Reprod Toxicol 65:87-94
Padilla, Cindy M; Kihal-Talantikit, Wahida; Vieira, Verónica M et al. (2016) City-Specific Spatiotemporal Infant and Neonatal Mortality Clusters: Links with Socioeconomic and Air Pollution Spatial Patterns in France. Int J Environ Res Public Health 13:
Townley, Ian K; Karchner, Sibel I; Skripnikova, Elena et al. (2016) Sequence and functional characterization of hypoxia inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus. Am J Physiol Regul Integr Comp Physiol :ajpregu.00402.2016
Bolt, Alicia M; Grant, Michael P; Wu, Ting Hua et al. (2016) Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells. Toxicol Sci 150:333-46
Pennell, Kelly G; Scammell, Madeleine K; McClean, Michael D et al. (2016) Field data and numerical modeling: A multiple lines of evidence approach for assessing vapor intrusion exposure risks. Sci Total Environ 556:291-301

Showing the most recent 10 out of 355 publications