The Community Outreach Core is an environmental justice project involving the communication and sharing of SBRP-generated knowledge and tools with Tribal communities affected by hazardous waste sites and toxicants. The applicants will use a Tribal Regional Workbench approach to enabling equitable environmental stewardship of Indian Reservations. The broad objective is to shift the emphasis from risk assessment as a disease paradigm to risk assessment as a wellness paradigm that embraces Tribal Traditional Lifeways. This new approach is identified as a high priority by the U.S. EPA's National Tribal Science Council, the National Tribal Environmental Council (NTEC), and Tribal environmental protection agencies. They will directly collaborate with Tribal communities both locally, 1) the Campo Indian Reservation, part of the Kumeyaay Nation;2) the Tribal environmental lab located at the Twenty-Nine Palms Band of Mission Indians, and nationally: 3) the Superfund Project Group of NTEC. These communities include prominent Tribal scientists who will help us create a unique Tribal information system that will be called the Tribal Regional Workbench (modeled after the UCSD SBRP Regional Workbench). The Tribal-RWB will be developed as a forum and an ensemble of datasets and information and knowledge integration tools to support online analysis, visualization and communication of environmental justice and quality of life issues explored within the Core's collaborative projects. The Community Outreach Core has five aims, grouped into two broad categories: Communication and Environmental Justice, and Knowledge Systems Integration.
Specific Aims i nclude 1a) to build a Tribal Regional Workbench Web site;1b) to share SBRP-generated knowledge and tools;2a) to host a regional gathering of tribal leaders and scientists;2b) to facilitate training opportunities for graduate and undergraduate students;and 3c) to co-investigator a series of papers, articles, and other publications with Tribal partners.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010337-10
Application #
7799244
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
10
Fiscal Year
2009
Total Cost
$127,166
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hsu, Po-Kai; Takahashi, Yohei; Munemasa, Shintaro et al. (2018) Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980
Dhar, Debanjan; Antonucci, Laura; Nakagawa, Hayato et al. (2018) Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell 33:1061-1077.e6
Febbraio, Mark A; Reibe, Saskia; Shalapour, Shabnam et al. (2018) Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab :
Fujiwara, Ryoichi; Yoda, Emiko; Tukey, Robert H (2018) Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33:9-16
Hartmann, Phillipp; Hochrath, Katrin; Horvath, Angela et al. (2018) Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology 67:2150-2166
Ganguly, Abantika; Guo, Lan; Sun, Lingling et al. (2018) Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. PLoS Genet 14:e1007595
Tripathi, Anupriya; Debelius, Justine; Brenner, David A et al. (2018) The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411
Chen, Shujuan; Tukey, Robert H (2018) Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos 46:1745-1755
Desai, Archita P; Mohan, Prashanthinie; Roubal, Anne M et al. (2018) Geographic Variability in Liver Disease-Related Mortality Rates in the United States. Am J Med 131:728-734
Ajmera, Veeral; Park, Charlie C; Caussy, Cyrielle et al. (2018) Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 155:307-310.e2

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