The Research Translation Core (RTC) will work with our Superfund Research Program (SRP) Center scientists and partners to identify ways in which cellular bioassays, chemical sensor-based technologies, and genetically engineered plants can be used to improve the detection and bioremediation of Superfund toxicants in water, sediment and soil. Our partnership approach builds on close working relationships we already have in place with tribes;industry;federal, state and regional government agencies, and SRP network colleagues nationally. The RTC will work closely with the 29 Palms Tribal EPA, the U.S. EPA and all the UCSD SRP labs. The overarching objective is twofold: first, increase the capacity of Tribal Nations to use cutting-edge biomolecular and chemical sensor-based technologies for detecting and bioremediating Superfund toxicants;and second, identify SRP science and technology applications through a process of learn-by-doing that have potential for commercial use by tribes as well as others concerned about protecting environmental and human health. The RTC has four specific aims: 1) Strengthen our long-standing partnership with the 29 Palms Tribal EPA in Coachella, California, 2) Field test and fine-tune new SRP technologies under real world conditions;3) Create a publically accessible web application for scientific mapping and spatial analysis of Superfund toxicants;and 4) Effectively disseminate emerging knowledge and technologies to broad audiences to accelerate social learning and practical applications of SRP research findings. To achieve these Aims we will identify and coordinate research translation opportunities with each SRP project, communicate with SRP staff at NIEHS, and do joint ventures with other SRP Centers nationwide (including a forum about tribal science and the value of university-tribal science partnerships). The RTC will work with the San Diego Industrial Environmental Association, and other partners, to host a series of Forums {Frontiers in New Biology) that encourage public discussion around the knowledge and technologies emanating from UCSD's SRP and from the national SRP network. We will systematically evaluate our progress toward meeting these aims using a logic model with input from our Center's internal advisory committee. We will share our progress and lessons learned with industry, the U.S.EPA, ATSDR, PEPH, and the NIEHS Research Translation network.

Public Health Relevance

The RTC translates SRP knowledge and lab technologies into applications that can improve environmental and public health by increasing the capacity of industry, citizen scientists and government, including Tribal EPAs, to detect, analyze and bioremediate Superfund toxicants.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010337-12
Application #
8463192
Study Section
Special Emphasis Panel (ZES1-JAB-J)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
12
Fiscal Year
2013
Total Cost
$175,692
Indirect Cost
$73,169
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wei, Zong; Yoshihara, Eiji; He, Nanhai et al. (2018) Vitamin D Switches BAF Complexes to Protect ? Cells. Cell 173:1135-1149.e15
Caussy, Cyrielle; Hsu, Cynthia; Lo, Min-Tzu et al. (2018) Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology :
McNulty, Reginald; Cardone, Giovanni; Gilcrease, Eddie B et al. (2018) Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release. Biophys J 114:1295-1301
Song, Na-Young; Zhu, Feng; Wang, Zining et al. (2018) IKK? inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A 115:E812-E821
Song, Isabelle Jingyi; Yang, Yoon Mee; Inokuchi-Shimizu, Sayaka et al. (2018) The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer 142:81-91
Hoffmann, Hanne; Pandolfi, Erica; Larder, Rachel et al. (2018) Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology :
Dow, Michelle; Pyke, Rachel M; Tsui, Brian Y et al. (2018) Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888
Kim, Ju Youn; Garcia-Carbonell, Ricard; Yamachika, Shinichiro et al. (2018) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell 175:133-145.e15
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306
Fan, Weiwei; He, Nanhai; Lin, Chun Shi et al. (2018) ERR? Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1?/?-Deficient Muscle. Cell Rep 22:2521-2529

Showing the most recent 10 out of 404 publications