The first goal of this project is to continue to lower the exposure to arsenic (As) of a cohort of 24,000 men and women recruited under the Health Effects of Arsenic Longitudinal Study (HEALS). This will be achieved by testing the numerous household wells that continue to be installed within the study area of Araihazar, using both laboratory measurements and field kits with support from Core C. In addition, the 110 deep community wells installed in some of the most affected portions of the study area will continue to be monitored. Beyond the ethical motivation, lowering exposure will help define exposure estimates of the studypopulation and, therefore, the dose-response relationships for various end-points studied under Projects 1, 2, and 3. The second goal of the project is to improve our understanding of the processes that threaten the quality of groundwater in aquifers that are presently low in As in Bangladesh by conducting field investigations. To determine the vulnerability of shallow (<30 m) aquifers that are tapped by most household wells, a ~1 km2 open field area located between a high-As and a low-As village of Araihazar will be densely instrumented and monitored for an entire year. Four ponds will then be dug and a nearby area raised with the fill to simulate the rural development of the region. The impact of this perturbation on the local hydrology and biogeochemistry (including As) of the perturbed areas, as well as two unperturbed controls, will be monitored for three years. To determine the vulnerability of deeper (>100 m) low-As aquifers, the origin of the failure of a handful of community wells in Araihazar will be investigated using a combination of geophysical, hydrological, and biogeochemical approaches supported under Project 4 and Cores C and D. The potential for downward incursion of shallow high-As groundwater on a broader scale due to intensive deep pumping below the city of Dhaka will be evaluated and modeled. These investigations will be carried out in the country where the health impact of As release to groundwater is by far the largest worldwide.

Public Health Relevance

Untreated groundwater is the main source of human exposure to As in both the US and in Bangladesh. Private wells will continue to be used in rural areas of both countries in the future;their vulnerability is therefore a public health issue. The understanding of As adsorption and transport that will result from this research is relevant to aquifers that are naturally elevated in As as well as contaminated Superfund sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES010349-11
Application #
8262915
Study Section
Special Emphasis Panel (ZES1-JAB-J (SF))
Project Start
Project End
Budget Start
2012-04-20
Budget End
2013-03-31
Support Year
11
Fiscal Year
2012
Total Cost
$218,340
Indirect Cost
$77,603
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
McClintock, Tyler R; Parvez, Faruque; Wu, Fen et al. (2016) Major dietary patterns and carotid intima-media thickness in Bangladesh. Public Health Nutr 19:218-29
Sun, Jing; Bostick, Benjamin C; Mailloux, Brian J et al. (2016) Effect of oxalic acid treatment on sediment arsenic concentrations and lability under reducing conditions. J Hazard Mater 311:125-33
Flanagan, Sara V; Spayd, Steven E; Procopio, Nicholas A et al. (2016) Arsenic in private well water part 2 of 3: Who benefits the most from traditional testing promotion? Sci Total Environ 562:1010-8
Khan, Mahfuzur R; Koneshloo, Mohammad; Knappett, Peter S K et al. (2016) Megacity pumping and preferential flow threaten groundwater quality. Nat Commun 7:12833
Howe, Caitlin G; Liu, Xinhua; Hall, Megan N et al. (2016) Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiol Biomarkers Prev :
Newman, Jonathan D; Navas-Acien, Ana; Kuo, Chin-Chi et al. (2016) Peripheral Arterial Disease and Its Association With Arsenic Exposure and Metabolism in the Strong Heart Study. Am J Epidemiol 184:806-817
Wasserman, Gail A; Liu, Xinhua; Parvez, Faruque et al. (2016) Child Intelligence and Reductions in Water Arsenic and Manganese: A Two-Year Follow-up Study in Bangladesh. Environ Health Perspect 124:1114-20
Sanchez, Tiffany R; Perzanowski, Matthew; Graziano, Joseph H (2016) Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review. Environ Res 147:537-55
Liu, Xinhua; Jin, Zhezhen; Graziano, Joseph H (2016) Comparing paired biomarkers in predicting quantitative health outcome subject to random censoring. Stat Methods Med Res 25:447-57
Sun, Jing; Chillrud, Steven N; Mailloux, Brian J et al. (2016) Enhanced and stabilized arsenic retention in microcosms through the microbial oxidation of ferrous iron by nitrate. Chemosphere 144:1106-15

Showing the most recent 10 out of 281 publications