This proposal is submitted in response to RFA-ES-10-010, entitled """"""""Superfund Hazardous Substance Research and Training Program (P42)."""""""" The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS);2) Consequences of As and Mn Exposure on Children's Health;and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic;5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites;and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management;9) Trace Metals;10) Biogeochemistry;and 11) Hydrogeology. A Research Translation Core (RTC) entitled, """"""""Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater"""""""" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled """"""""Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine."""""""" The CEC has developed naturally from our past biomedical and geochemical As research in Maine.

Public Health Relevance

The contamination of groundwater and soils with As and Mn are associated with major public health, remedial, and environmental policy problems. Both As and Mn are found at numerous Superfund sites. This competitive renewal proposal seeks to obtain fundamental new knowledge concerning the health effects, geochemistry, and remediation of As and Mn, with a particular focus on groundwater. Knowledge obtained from this research will have direct implications for remediation at contaminated sites and for the improvement of public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010349-12
Application #
8461577
Study Section
Special Emphasis Panel (ZES1-JAB-J (SF))
Program Officer
Carlin, Danielle J
Project Start
2000-06-01
Project End
2017-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
12
Fiscal Year
2013
Total Cost
$2,844,284
Indirect Cost
$860,916
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Howe, Caitlin G; Liu, Xinhua; Hall, Megan N et al. (2016) Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiol Biomarkers Prev :
Newman, Jonathan D; Navas-Acien, Ana; Kuo, Chin-Chi et al. (2016) Peripheral Arterial Disease and Its Association With Arsenic Exposure and Metabolism in the Strong Heart Study. Am J Epidemiol 184:806-817
Wasserman, Gail A; Liu, Xinhua; Parvez, Faruque et al. (2016) Child Intelligence and Reductions in Water Arsenic and Manganese: A Two-Year Follow-up Study in Bangladesh. Environ Health Perspect 124:1114-20
Sanchez, Tiffany R; Perzanowski, Matthew; Graziano, Joseph H (2016) Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review. Environ Res 147:537-55
Liu, Xinhua; Jin, Zhezhen; Graziano, Joseph H (2016) Comparing paired biomarkers in predicting quantitative health outcome subject to random censoring. Stat Methods Med Res 25:447-57
Sun, Jing; Chillrud, Steven N; Mailloux, Brian J et al. (2016) Enhanced and stabilized arsenic retention in microcosms through the microbial oxidation of ferrous iron by nitrate. Chemosphere 144:1106-15

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