This proposal is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)." The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS);2) Consequences of As and Mn Exposure on Children's Health;and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic;5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites;and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management;9) Trace Metals;10) Biogeochemistry;and 11) Hydrogeology. A Research Translation Core (RTC) entitled, "Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from our past biomedical and geochemical As research in Maine.
The contamination of groundwater and soils with As and Mn are associated with major public health, remedial, and environmental policy problems. Both As and Mn are found at numerous Superfund sites. This competitive renewal proposal seeks to obtain fundamental new knowledge concerning the health effects, geochemistry, and remediation of As and Mn, with a particular focus on groundwater. Knowledge obtained from this research will have direct implications for remediation at contaminated sites and for the improvement of public health.
|Flanagan, Sara V; Marvinney, Robert G; Zheng, Yan (2015) Influences on domestic well water testing behavior in a Central Maine area with frequent groundwater arsenic occurrence. Sci Total Environ 505:1274-81|
|Flanagan, Sara V; Marvinney, Robert G; Johnston, Robert A et al. (2015) Dissemination of well water arsenic results to homeowners in Central Maine: influences on mitigation behavior and continued risks for exposure. Sci Total Environ 505:1282-90|
|Brocato, Jason; Costa, Max (2015) 10th NTES Conference: Nickel and arsenic compounds alter the epigenome of peripheral blood mononuclear cells. J Trace Elem Med Biol 31:209-13|
|McClintock, Tyler R; Chen, Yu; Parvez, Faruque et al. (2014) Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol 276:21-7|
|Argos, Maria; Tong, Lin; Pierce, Brandon L et al. (2014) Genome-wide association study of smoking behaviours among Bangladeshi adults. J Med Genet 51:327-33|
|Zheng, Wei; McLerran, Dale F; Rolland, Betsy A et al. (2014) Burden of total and cause-specific mortality related to tobacco smoking among adults aged ? 45 years in Asia: a pooled analysis of 21 cohorts. PLoS Med 11:e1001631|
|McClintock, Tyler R; Parvez, Faruque; Wu, Fen et al. (2014) Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh. Int J Epidemiol 43:1174-82|
|Knappett, P S K; Du, J; Liu, P et al. (2014) Importance of Reversible Attachment in Predicting E. Coli Transport in Saturated Aquifers From Column Experiments. Adv Water Resour 63:120-130|
|Argos, Maria; Parvez, Faruque; Rahman, Mahfuzar et al. (2014) Arsenic and lung disease mortality in Bangladeshi adults. Epidemiology 25:536-43|
|van Geen, Alexander; Win, Kyi Htut; Zaw, Than et al. (2014) Confirmation of elevated arsenic levels in groundwater of Myanmar. Sci Total Environ 478:21-4|
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