Arsenic groundwater concentrations are determined in part by their sediment concentration but also by sediment mineralogy and the transformations that affect them. The first goal of this project is to examine the spatial distribution of aqueous As (and other analytes) within the comprehensive sampling efforts outlined in Projects 5 (Vineland), 6 (Bangladesh) and Cores to link groundwater As levels to tangible aqueous and sediment properties (e.g., mineralogy, measured using state-of-the-art spectroscopic methods including Fe, As, and S X-ray spectroscopy) and the biological communities that transform them (with 16 rDNA community libraries and functional gene analysis). As part of this comprehensive effort, this project will characterize the Fe, As and S phases that regulate dissolved As concentrations, identify active redox processes in the aquifer that affect these phases and the bacteria that facilitate these processes, and determine which active carbon pools drive microbial respiration. The second overarching goal of this project is to examine the role of transformations in sediment mineralogy and aquifer geochemistry on arsenic levels. Within the simulated pond-village in Araihazar, and the Vineland Superfund Site, we will study the relationship between sediment mineralogy, redox status, microbial populations and arsenic levels, but we will also be able to monitor how those and other parameters change over time in controlled laboratory experiments. These batch and column studies will use natural sediments and will probe the effect of perturbations of geochemical conditions on sediment biogeochemical processes, Fe, S and As mineralogies, and As geochemistry. These manipulations will directly probe the question of the effect of human activity on As contamination (applicable to Proj. 6 goals), and will allow us to examine the rates of relevant and fundamental environmental processes for the first time. The resulting data will then be used to develop and calibrate reactive transport models that more accurately capture the processes that affect As partitioning (Proj. 5, 6, Hydrogeology Core). These data also will be used to engineer improved remediation solutions at the Vineland Superfund site.
Arsenic is ubiquitous, yet groundwater concentrations, the principal route of human exposure, are highly variable. An improved understanding of the processes that regulate arsenic levels is needed identify safe and contaminated water supplies and thus minimize the risks of this contamination. Fundamental knowledge of the biogeochemical processes that affect As levels is therefore directly relevant to public health.
|Sun, Jing; Mailloux, Brian J; Chillrud, Steven N et al. (2018) Simultaneously Quantifying Ferrihydrite and Goethite in Natural Sediments Using the Method of Standard Additions with X-ray Absorption Spectroscopy. Chem Geol 476:248-259|
|Argos, Maria; Tong, Lin; Roy, Shantanu et al. (2018) Screening for gene-environment (G×E) interaction using omics data from exposed individuals: an application to gene-arsenic interaction. Mamm Genome 29:101-111|
|Wu, Fen; Chi, Liang; Ru, Hongyu et al. (2018) Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults. Environ Health Perspect 126:017005|
|Sanchez, Tiffany R; Powers, Martha; Perzanowski, Matthew et al. (2018) A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease? Curr Environ Health Rep 5:244-254|
|Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296|
|Sanchez, Tiffany R; Slavkovich, Vesna; LoIacono, Nancy et al. (2018) Urinary metals and metal mixtures in Bangladesh: Exploring environmental sources in the Health Effects of Arsenic Longitudinal Study (HEALS). Environ Int 121:852-860|
|Spratlen, Miranda J; Grau-Perez, Maria; Umans, Jason G et al. (2018) Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740|
|Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129|
|Oliver-Williams, Clare; Howard, Annie Green; Navas-Acien, Ana et al. (2018) Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. J Am Soc Hypertens 12:426-437.e9|
|Jones, Miranda R; Tellez-Plaza, Maria; Vaidya, Dhananjay et al. (2018) Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA). J Expo Sci Environ Epidemiol :|
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