The first goal of this project is to continue to lower the exposure to arsenic (As) of a cohort of 24,000 men and women recruited under the Health Effects of Arsenic Longitudinal Study (HEALS). This will be achieved by testing the numerous household wells that continue to be installed within the study area of Araihazar, using both laboratory measurements and field kits with support from Core C. In addition, the 110 deep community wells installed in some of the most affected portions of the study area will continue to be monitored. Beyond the ethical motivation, lowering exposure will help define exposure estimates of the studypopulation and, therefore, the dose-response relationships for various end-points studied under Projects 1, 2, and 3. The second goal of the project is to improve our understanding of the processes that threaten the quality of groundwater in aquifers that are presently low in As in Bangladesh by conducting field investigations. To determine the vulnerability of shallow (<30 m) aquifers that are tapped by most household wells, a ~1 km2 open field area located between a high-As and a low-As village of Araihazar will be densely instrumented and monitored for an entire year. Four ponds will then be dug and a nearby area raised with the fill to simulate the rural development of the region. The impact of this perturbation on the local hydrology and biogeochemistry (including As) of the perturbed areas, as well as two unperturbed controls, will be monitored for three years. To determine the vulnerability of deeper (>100 m) low-As aquifers, the origin of the failure of a handful of community wells in Araihazar will be investigated using a combination of geophysical, hydrological, and biogeochemical approaches supported under Project 4 and Cores C and D. The potential for downward incursion of shallow high-As groundwater on a broader scale due to intensive deep pumping below the city of Dhaka will be evaluated and modeled. These investigations will be carried out in the country where the health impact of As release to groundwater is by far the largest worldwide.

Public Health Relevance

Untreated groundwater is the main source of human exposure to As in both the US and in Bangladesh. Private wells will continue to be used in rural areas of both countries in the future;their vulnerability is therefore a public health issue. The understanding of As adsorption and transport that will result from this research is relevant to aquifers that are naturally elevated in As as well as contaminated Superfund sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010349-12
Application #
8461587
Study Section
Special Emphasis Panel (ZES1-JAB-J)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
12
Fiscal Year
2013
Total Cost
$216,877
Indirect Cost
$80,162
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Sun, Jing; Mailloux, Brian J; Chillrud, Steven N et al. (2018) Simultaneously Quantifying Ferrihydrite and Goethite in Natural Sediments Using the Method of Standard Additions with X-ray Absorption Spectroscopy. Chem Geol 476:248-259
Argos, Maria; Tong, Lin; Roy, Shantanu et al. (2018) Screening for gene-environment (G×E) interaction using omics data from exposed individuals: an application to gene-arsenic interaction. Mamm Genome 29:101-111
Wu, Fen; Chi, Liang; Ru, Hongyu et al. (2018) Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults. Environ Health Perspect 126:017005
Sanchez, Tiffany R; Powers, Martha; Perzanowski, Matthew et al. (2018) A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease? Curr Environ Health Rep 5:244-254
Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296
Sanchez, Tiffany R; Slavkovich, Vesna; LoIacono, Nancy et al. (2018) Urinary metals and metal mixtures in Bangladesh: Exploring environmental sources in the Health Effects of Arsenic Longitudinal Study (HEALS). Environ Int 121:852-860
Spratlen, Miranda J; Grau-Perez, Maria; Umans, Jason G et al. (2018) Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740
Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129
Oliver-Williams, Clare; Howard, Annie Green; Navas-Acien, Ana et al. (2018) Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. J Am Soc Hypertens 12:426-437.e9
Jones, Miranda R; Tellez-Plaza, Maria; Vaidya, Dhananjay et al. (2018) Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA). J Expo Sci Environ Epidemiol :

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