Biomarkers of exposure to metals and metalloids have proven to be powerful tools for epidemiologic studies that seek to study associations between exposures and human health effects. The Trace Metal Facility Core Laboratory is an established facility that is jointly supported by the Columbia University P30 NIEHS Center and this SBRP. The laboratory enables numerous investigators to precisely measure a broad range of metals, metabolites, and proteins in biological specimens. The NIEHS Center budget provides support for instrumentation, some (but not all) service contracts, methods development, and pilot study analyses, as well as partial support for the Laboratory Director and the Laboratory Manager. In the current proposal, three biomedical projects (Projects #1, #2 and #3) collectively have proposed that roughly 65,000 biological specimens be analyzed by this Core during the next five years. Thus, the Core requests funding to support the increased personnel and supply costs associated with these services. This laboratory participates in numerous quality control programs and, in that regard, its performance during the past grant cycle has been outstanding. It has anayzed more than 80,000 biological samples during the past five years, supporting many novel research findings derived from four biomedical research projects. The laboratory is equipped with four atomic absorption spectrophotometers, including three graphite furnace instruments. The laboratory also has ICP-MS-DRC instrumentation that allows for the simultaneous measurement of low concentrations of multiple elements in biological samples. The analytical methods to be conducted during the next five years include many that are already in place including: total As and creatinine in urine;Pb, As, and Se in blood;As metabolites in urine and blood. As in toenails, and other methods. One year ago, the Trace Metals Core Laboratory moved into larger and newly renovated space.

Public Health Relevance

The availability of a core laboratory that can measure a suite of elements in biological samples has served as a major resource to many investigators in our Superfund Research Program. Most of the biomedical discoveries that have arisen from our program over the past decade have benefited directly from the technical and analytical support of this laboratory.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-JAB-J)
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Columbia University (N.Y.)
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Flanagan, Sara V; Marvinney, Robert G; Zheng, Yan (2015) Influences on domestic well water testing behavior in a Central Maine area with frequent groundwater arsenic occurrence. Sci Total Environ 505:1274-81
Flanagan, Sara V; Marvinney, Robert G; Johnston, Robert A et al. (2015) Dissemination of well water arsenic results to homeowners in Central Maine: influences on mitigation behavior and continued risks for exposure. Sci Total Environ 505:1282-90
Brocato, Jason; Costa, Max (2015) 10th NTES Conference: Nickel and arsenic compounds alter the epigenome of peripheral blood mononuclear cells. J Trace Elem Med Biol 31:209-13
McClintock, Tyler R; Chen, Yu; Parvez, Faruque et al. (2014) Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol 276:21-7
Argos, Maria; Tong, Lin; Pierce, Brandon L et al. (2014) Genome-wide association study of smoking behaviours among Bangladeshi adults. J Med Genet 51:327-33
Zheng, Wei; McLerran, Dale F; Rolland, Betsy A et al. (2014) Burden of total and cause-specific mortality related to tobacco smoking among adults aged ? 45 years in Asia: a pooled analysis of 21 cohorts. PLoS Med 11:e1001631
McClintock, Tyler R; Parvez, Faruque; Wu, Fen et al. (2014) Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh. Int J Epidemiol 43:1174-82
Knappett, P S K; Du, J; Liu, P et al. (2014) Importance of Reversible Attachment in Predicting E. Coli Transport in Saturated Aquifers From Column Experiments. Adv Water Resour 63:120-130
Argos, Maria; Parvez, Faruque; Rahman, Mahfuzar et al. (2014) Arsenic and lung disease mortality in Bangladeshi adults. Epidemiology 25:536-43
van Geen, Alexander; Win, Kyi Htut; Zaw, Than et al. (2014) Confirmation of elevated arsenic levels in groundwater of Myanmar. Sci Total Environ 478:21-4

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