The Administrative Core provides a formal structure for oversight and planning of the Center's research and other activities. It provides the mechanism for coordination among the research projects and the service cores. This Core also functions in tandem with the Research Translation Core and the Center's educational component, the Training Core. The Core is organized around the PI and two committees - the External Advisory Committee and the Executive Committee.
The specific aims of the Administrative Core are as follows: 1. Central Planning and Coordination: To monitor and maintain research progress and effective communication among Center investigators;to ensure exchange of information between research projects and Research Translation, Analytical, Neural Behavior-Toxicity and Training Cores. To ensure timely review of progress in all aspects of the Center's operations;to maintain an environment that promotes cross-discipline interactions among the projects and cores. 2. Fiscal Responsibility and Oversight: To monitor and review allocation of financial resources within the center and to re-allocate funds as appropriate to foster the Center's overall objectives. The Core also ensures compliance with Federal and internal institutional grant regulations. 3. To Facilitate Communications: In concert with the Research Translation Core, the Administrative Core is the central hub for communication between NIEHS and SRP staff with the Principal Investigator being the primary point of contact. 4. To Coordinate Center Events and Educational Opportunities: The Center's Manager will work closely with Dr. Edward Levin, PI of the Training Core, to coordinate and promote weekly seminars and semi-annual symposia. 5. Student Liaison: In conjunction with the aims of the Training Core, the Center Manager will serve as a primary point of contact with the Center's undergraduate, graduate and postdoctoral students to ensure that students and Center Investigators are aware of educational opportunities within the Center and are in compliance with Institutional and SRP regulations.

Public Health Relevance

The overarching goal of this Superfund Research Center is a broad understanding of chemical impacts on developing organisms and approaches for reducing these impacts. The Administrative Core will strive to insure that this goal is met through the appropriate integration of the Center's multidisciplinary investigators and students, and Center results are effectively translated to the SRP, other researchers, policy-makers, and the public.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Duke University
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Oliveri, Anthony N; Ortiz, Erica; Levin, Edward D (2018) Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30
Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2018) Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. Toxicology 400-401:57-64
Lefèvre, Emilie; Bossa, Nathan; Gardner, Courtney M et al. (2018) Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110
Kollitz, Erin M; Kassotis, Christopher D; Hoffman, Kate et al. (2018) Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor ? Signaling. Environ Sci Technol :
Hartman, Jessica H; Smith, Latasha L; Gordon, Kacy L et al. (2018) Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep 8:8359
Luz, Anthony L; Kassotis, Christopher D; Stapleton, Heather M et al. (2018) The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPAR? activation, in 3T3-L1 cells. Toxicology 393:150-159
Day, D B; Xiang, J; Mo, J et al. (2018) Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. Indoor Air 28:360-372
Slotkin, Theodore A; Ko, Ashley; Seidler, Frederic J (2018) Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems? Toxicology 408:11-21
Rock, Kylie D; Horman, Brian; Phillips, Allison L et al. (2018) EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain. Endocr Connect 7:305-324
Weinhouse, Caren; Truong, Lisa; Meyer, Joel N et al. (2018) Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575

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