The Analytical Chemistry Core (ACC;Core B) will be a new addition to Duke University's established Superfund Research Center (SRC). The mission of Duke's SRC has been and continues to be identifying the expression and mechanisms of developmental effects from early life exposure to Superfund chemicals and their transformation products. Addition of an analytical chemistry core to this center will enhance the biomedical and non-biomedical projects by providing state-of-the-art analytical support to monitor and quantify organic contaminant levels which can aid in identifying mechanisms of developmental toxicity. Adding the support of an ACC will provide the means of evaluating key relationships between exposures and body burdens, which will help determine what the potential biological """"""""costs"""""""" of early life exposures are for both humans and ecosystems;and furthermore, to determine whether or not remediation strategies are effective or if they increase these costs. The ACC will provide services for routine analyses of samples for organophosphate pesticides (e.g. chlorpyrifos), polycyclic aromatic hydrocarbons (PAHs), and brominated flame retardants (e.g. polybrominated diphenyl ethers) levels. In addition this core will assist in the identification of contaminant degradation products and/or metabolites which will be examined in several research projects. Lastly, the ACC will also serve as a teaching and training center for Duke University undergraduate and graduate students. The ACC will be supervised by Dr. P. Lee Ferguson, an Associate Professor of Environmental Science &Engineering with over ten years of experience in environmental mass spectrometry and trace analysis. Dr. Heather M. Stapleton, an Assistant Professor of Environmental Science and experienced trace analytical chemist, will serve as co-principal investigator and help manage the ACC. Drs. Ferguson and Stapleton currently supervise research laboratories equipped for high through-put extraction and analysis of samples for trace organic chemicals using a combination of gas chromatography mass spectrometry (GC/MS), liquid chromatography tandem mass spectrometry (HPLC/MS-MS), and high resolution mass spectrometry (HPLC/Orbitrap MS).

Public Health Relevance

The function of this Analytical Chemistry Core (Core B) will be to provide routine sample analysis and monitoring of Superfund contaminants examined in individual biomedical and non-biomedical projects, and in identifying degradation products and/or metabolites of these Superfund contaminants. This service will be utilized by all projects detailed in Duke's Superfund Research Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010356-12
Application #
8450250
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
12
Fiscal Year
2013
Total Cost
$271,927
Indirect Cost
$124,718
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Oliveri, Anthony N; Ortiz, Erica; Levin, Edward D (2018) Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30
Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2018) Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. Toxicology 400-401:57-64
Lefèvre, Emilie; Bossa, Nathan; Gardner, Courtney M et al. (2018) Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110
Kollitz, Erin M; Kassotis, Christopher D; Hoffman, Kate et al. (2018) Chemical Mixtures Isolated from House Dust Disrupt Thyroid Receptor ? Signaling. Environ Sci Technol :
Hartman, Jessica H; Smith, Latasha L; Gordon, Kacy L et al. (2018) Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep 8:8359
Luz, Anthony L; Kassotis, Christopher D; Stapleton, Heather M et al. (2018) The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPAR? activation, in 3T3-L1 cells. Toxicology 393:150-159
Day, D B; Xiang, J; Mo, J et al. (2018) Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults. Indoor Air 28:360-372
Slotkin, Theodore A; Ko, Ashley; Seidler, Frederic J (2018) Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems? Toxicology 408:11-21
Rock, Kylie D; Horman, Brian; Phillips, Allison L et al. (2018) EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain. Endocr Connect 7:305-324
Weinhouse, Caren; Truong, Lisa; Meyer, Joel N et al. (2018) Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575

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