The goal of Project 4 is to elucidate the separate and combined effects of nanomaterial-based processes and microbial degradation on transformations of target Superfund chemicals, to better understand how nanomaterial-based remediation technologies might be best applied and, to achieve a maximum reduction in toxicity using combined nano-bio remediation. In addition, we seek to understand the potential impacts of nanomaterials themselves on the microbial ecology in sediments. The target contaminants for this study include an organophosphate insecticide (chlorpyrifos), a representative polycyclic aromatic hydrocarbon (benzo[a]pyrene), and a polybrominated flame retardant (decabrominated diphenyl ether, BDE-209). The pervasiveness of these compounds has resulted in a significant need for remediation-strategies to ameliorate their toxicity;however, care must be taken to ensure that remediation techniques do not result in increased toxicity or adverse effects from the use of the technology and/or the degradation products. This project studies remediation using zero valent iron (ZVI) and titanium dioxide (Ti02) nanomaterials for contaminant degradation. Our objectives are to: 1) Investigate the use of nanomaterials as catalysts for direct treatment of sediment and water contaminated by developmental toxicants;2) Assess microbial degradation of the target contaminants by sediment microorganisms with and without nanomaterials;and 3) Uncover possible synergies (or unintended antagonistic effects) of nanoparticle-based remediation with natural microbial degradation processes.

Public Health Relevance

This project will provide guidance for the possible application of TiO2 or ZVI nanoparticles in remediating contaminated sites to achieve long-term degradation of targeted compounds through source treatment combined with in-situ natural attenuation, as well as treatment of dredged material.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010356-13
Application #
8659453
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
13
Fiscal Year
2014
Total Cost
$388,598
Indirect Cost
$130,184
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Garner, Lindsey V T; Brown, Daniel R; Di Giulio, Richard T (2013) Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquat Toxicol 142-143:336-46
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