This program addresses the synergistic interactions of combustion-generated organic pollutants and particles that increase their chemical and, biological activity. Program goals include: 1) understand the relationships'.between'the. origin, mechanisms of formation, nature of emissions;biological availability;and biological activitybttoxic combustion by-products such that;2) improved, health effects-engineered, thermal treatment technologies can be developed;and 3) intelligent fisk^based decisions can be made concerning on-site versus offsite treatment and thermal versus non-thermal treatment options of Superfund Wastes. Our research will focus on the origin and health impacts of four classes of pollutants: 1) combustiongenerated ultra-fine particles (UFPs), 2) persistent free radicals (PFRs), 3) chlorinated hydrocarbons (CHQs), and 4). brorninated hydrocarbons (BHGs). Combustion generates UFPs or """"""""nanoparticies"""""""" with diameters less than?0i1:rnicrcons-.whieh;have7been linked to:the'health impacts, of airborne PM2.5.1 OHCs and;BHCs consistently rankamong the most significant chemicals of concern at Superfund sites, and their thermal degradation is known to create toxic by-products including polychlorinated and brorninated dibenzcp-dioxins and dibenzofurans. We will specifically focus on the role of chemisorption.of CHCs and BHCs on UFPs to form surface-stabilized PFRs that can generate oxidative stress in exposed individuals as well as be key intermediates in the formation of new pollutants. PFRs are a new class of pollutants that may be responsible for some of the observed health impacts of UFPs and has been the subject of unique research by key members of our research team for the past 3 years. In this proposal, a multidisciplinary team of biomedical, biological, chemical, and engineering researchers in addition to environmental policy scientists will address the lihksvbetween human health impacts of toxic;air pollutants and combustion/thermal processing of hazardous wastes., this program is truly interdisciplinary as!it has a specific goal of establishing the nature of this link, and as such will require each group of researchers to go beyond their traditionally narrow veins of research and to integrate their understanding. The program consists of: three biomedical projects, three non-biomedical projects, four research support cores, an administrative core, a research translation core, a community outreach core, and a training core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES013648-02S1
Application #
8213946
Study Section
Special Emphasis Panel (ZES1-JAB-C (S7))
Program Officer
Carlin, Danielle J
Project Start
2009-08-15
Project End
2011-08-31
Budget Start
2010-08-04
Budget End
2011-08-31
Support Year
2
Fiscal Year
2011
Total Cost
$20,000
Indirect Cost
Name
Louisiana State University A&M Col Baton Rouge
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Reed, James R; Backes, Wayne L (2017) Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures. Front Pharmacol 8:28
Shrestha, Bishwas; You, Dahui; Saravia, Jordy et al. (2017) IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol 102:153-161
Connick, John Patrick; Reed, James R; Backes, Wayne L (2017) Characterization of interactions among CYP1A2, CYP2B4, and NADPH-cytochrome P450 reductase: Identification of specific protein complexes. Drug Metab Dispos :
Patterson, Matthew C; DiTusa, Mark F; McFerrin, Cheri A et al. (2017) Formation of environmentally persistent free radicals (EPFRs) on ZnO at room temperature: Implications for the fundamental model of EPFR generation. Chem Phys Lett 670:5-10
Oyana, Tonny J; Lomnicki, Slawomir M; Guo, Chuqi et al. (2017) A Scalable Field Study Protocol and Rationale for Passive Ambient Air Sampling: A Spatial Phytosampling for Leaf Data Collection. Environ Sci Technol 51:10663-10673
Feld-Cook, Elisabeth E; Bovenkamp-Langlois, Lisa; Lomnicki, Slawo M (2017) Effect of Particulate Matter Mineral Composition on Environmentally Persistent Free Radical (EPFR) Formation. Environ Sci Technol 51:10396-10402
Deese, Rachel D; Weldeghiorghis, Thomas K; Haywood, Benjamin J et al. (2017) Influence of surfactants and humic acids on Artemia Franciscana's embryonic phospho-metabolite profile as measured by 31P NMR. Aquat Toxicol 186:188-195
Jaligama, Sridhar; Saravia, Jordy; You, Dahui et al. (2017) Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter. Respir Res 18:15
Chuang, Gin C; Xia, Huijing; Mahne, Sarah E et al. (2017) Environmentally Persistent Free Radicals Cause Apoptosis in HL-1 Cardiomyocytes. Cardiovasc Toxicol 17:140-149
Deese, Rachel D; LeBlanc, Madeline R; Cook, Robert L (2016) Surfactant toxicity to Artemia Franciscana and the influence of humic acid and chemical composition. Environ Chem 13:507-516

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