The goal of the Administrative Core (AC) is to foster innovative research by providing support services and leadership for the Program. The proposed program brings together biomedical and non-biomedical researchers to examine the human health impacts of fine particles and ultrafine particles contaminated with hazardous substances. The function of the Administrative Core is to provide overarching leadership to the program and manage resources. The AC will provide overall program management, sponsor interface, management, record keeping, and budget administration functions for the program. It will also coordinate the functions of the research projects, research support cores, and non-technical cores and oversee the transfer of samples among cores to ensure efficiency of the research efforts. The core is staffed by: 1) a Director, the program PI, Dr. Barry Dellinger;2) an Associate Director and co-Director for biomedical research. Dr. Wayne Backes, 3) an Assistant Director, Dr. Maud Walsh, and 4) an Administrative Assistant, Ms. Tina Black. In addition, Mr. Jerry Steward is the QA/QC and Health and Safety Officer and reports directly to Dr. Dellinger. External and internal advisory committees provide third-party advice to the PI and co-PI on the management and technical progress of the program. Communication within the program is facilitated by bi-weekly Project Leader staff meetings and monthly program meetings. The Project Leader meetings will be concerned with operational aspects of the program and communication of key research findings and questions. The monthly program meetings, which are open to all senior program personnel, post-doctoral fellows, and graduate students, will focus on research progress through a rotating seminar and question/discussion/answer session. On a quarterly basis, the monthly program meetings will also be used to apprise and update senior program personnel on current fiscal and resource matters for the program. The AC, with the help of the advisory committees, will work to identify and pursue additional funding sources for the program.

Public Health Relevance

The program's research has the potential to transform how the scientific community views mechanisms of initiation of environmental diseases by environmental fine and ultrafine particles. The Administrative Core supports the program goals by providing services that facilitate research and by steering the Program as new findings and new challenges emerge.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-SET-V (04))
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Louisiana State University A&M Col Baton Rouge
Baton Rouge
United States
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Reed, James R; Backes, Wayne L (2017) Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures. Front Pharmacol 8:28
Shrestha, Bishwas; You, Dahui; Saravia, Jordy et al. (2017) IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol 102:153-161
Connick, John Patrick; Reed, James R; Backes, Wayne L (2017) Characterization of interactions among CYP1A2, CYP2B4, and NADPH-cytochrome P450 reductase: Identification of specific protein complexes. Drug Metab Dispos :
Patterson, Matthew C; DiTusa, Mark F; McFerrin, Cheri A et al. (2017) Formation of environmentally persistent free radicals (EPFRs) on ZnO at room temperature: Implications for the fundamental model of EPFR generation. Chem Phys Lett 670:5-10
Oyana, Tonny J; Lomnicki, Slawomir M; Guo, Chuqi et al. (2017) A Scalable Field Study Protocol and Rationale for Passive Ambient Air Sampling: A Spatial Phytosampling for Leaf Data Collection. Environ Sci Technol 51:10663-10673
Feld-Cook, Elisabeth E; Bovenkamp-Langlois, Lisa; Lomnicki, Slawo M (2017) Effect of Particulate Matter Mineral Composition on Environmentally Persistent Free Radical (EPFR) Formation. Environ Sci Technol 51:10396-10402
Deese, Rachel D; Weldeghiorghis, Thomas K; Haywood, Benjamin J et al. (2017) Influence of surfactants and humic acids on Artemia Franciscana's embryonic phospho-metabolite profile as measured by 31P NMR. Aquat Toxicol 186:188-195
Jaligama, Sridhar; Saravia, Jordy; You, Dahui et al. (2017) Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter. Respir Res 18:15
Chuang, Gin C; Xia, Huijing; Mahne, Sarah E et al. (2017) Environmentally Persistent Free Radicals Cause Apoptosis in HL-1 Cardiomyocytes. Cardiovasc Toxicol 17:140-149
Deese, Rachel D; LeBlanc, Madeline R; Cook, Robert L (2016) Surfactant toxicity to Artemia Franciscana and the influence of humic acid and chemical composition. Environ Chem 13:507-516

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