The Materials Core provides samples of well-characterized Superfund-related particles and surrogates designed to test specific research hypotheses for study by the 6 research projects. The Core was constructed to assist in the study of the health and environmental effects of environmentally persistent free radicals (EPFRs) associated with transition metal-containing particulate matter (PM). Our researchers have discovered EPFRs are formed by chemisorption of aromatic chlorinated benzenes, chlorinated phenols, and other types of phenols to metal oxides, followed by electron transfer that reduces the metal and forms the EPFR. These EPFRs can persist in the environment and are biologically active. At high concentrations in combustion and thermal processing systems, they also self-react to form new pollutants such as polychlorinated dibenzo-p-dioxins and dibenzofurans. Because fine particles and ultrafine particles have high surface-to-volume ratios and increased reactivity due to unsatisfied valences, they may be particularly prone to EPFR formation. The Core has developed facilities and techniques to synthesize: i) fine and ultrafine particles of silica coated with a monolayer of transition metals such as copper oxide and iron oxide;ii) fine and ultrafine silica particles containing size-controlled nanodomains of the same transition metals;iii) ultrafine particles of pure copper and iron oxides;iv) any of these particles with associated environmentally persistent free radicals (EPFRs);and v) appropriate control samples. The Core has also established the capabilities to characterize field samples from contaminated Superfund soils and particulate emissions of devices for thermal treatment of hazardous substances for EPFRs using electron paramagnetic resonance (EPR) spectroscopy and molecular precursors using GC-MS and other standard laboratory techniques. The Core has developed systematic approaches for receiving sample requests, establishing chain of custody, and storing particles under vacuum where they will not degrade prior to use. The Core Director has a record of successful collaborations with each of the Project Leaders over the past 5 years, leading to multiple publications.
The Materials Core, in conjunction with Projects 1, 2, and 6, will, for the first time, characterize contaminated Superfund soils and PM from thermal treatment of Superfund wastes for environmentally persistent free radicals. The Core will provide researchers interested in studying EPFR-particle systems with characterized samples and surrogate pollutant-particle systems designed to test specific hypotheses.
|Hijano, Diego R; Siefker, David T; Shrestha, Bishwas et al. (2018) Type I Interferon Potentiates IgA Immunity to Respiratory Syncytial Virus Infection During Infancy. Sci Rep 8:11034|
|Haywood, Benjamin J; White, John R; Cook, Robert L (2018) Investigation of an early season river flood pulse: Carbon cycling in a subtropical estuary. Sci Total Environ 635:867-877|
|Connick, J Patrick; Reed, James R; Backes, Wayne L (2018) Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes. Drug Metab Dispos 46:197-203|
|Potter, Phillip M; Guan, Xia; Lomnicki, Slawomir M (2018) Synergy of iron and copper oxides in the catalytic formation of PCDD/Fs from 2-monochlorophenol. Chemosphere 203:96-103|
|Harmon, Ashlyn C; Hebert, Valeria Y; Cormier, Stephania A et al. (2018) Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells. PLoS One 13:e0205412|
|Jaligama, Sridhar; Patel, Vivek S; Wang, Pingli et al. (2018) Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor. Part Fibre Toxicol 15:20|
|Dugas, Tammy R (2018) Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease. Curr Opin Toxicol 7:1-8|
|Feld-Cook, Elisabeth E; Bovenkamp-Langlois, Lisa; Lomnicki, Slawo M (2017) Effect of Particulate Matter Mineral Composition on Environmentally Persistent Free Radical (EPFR) Formation. Environ Sci Technol 51:10396-10402|
|Chuang, Gin C; Xia, Huijing; Mahne, Sarah E et al. (2017) Environmentally Persistent Free Radicals Cause Apoptosis in HL-1 Cardiomyocytes. Cardiovasc Toxicol 17:140-149|
|Jaligama, Sridhar; Saravia, Jordy; You, Dahui et al. (2017) Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter. Respir Res 18:15|
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