Louisiana State University and the Health Sciences Centers in New Orleans and Shreveport have formed an interdisciplinary collaboration to perform research on the environmental and health impacts of pollutant-particle systems associated with Superfund sites. Our researchers have discovered chlorinated aromatic hydrocarbons and substituted phenols chemisorb to the surfaces of particulate matter containing redoxactive transition metals where they reduce the metal and form a free radical. These radicals are stabilized by association with surface, and their reactivity is reduced to the point that they can persist in the atmosphere for several days. Our biomedical researchers have shown these environmentally persistent free radicals (EPFRs) associated with ultrafine particulate matter are also persistent in biological media where they initiate long catalytic chain cycles resulting in production of >1000 hydroxyl radicals per EPFR. This promotes oxidative stress leading to induction of pulmonary and cardiac dysfunction as well as altering the expression of P450 enzyme. The EPFRs have been detected in contaminated soils at a Superfund wood-treating site and the fly-ash produced from incineration of hazardous substances. At high concentrations in thermal treatment devices, the EPFRs also promote the formation of new molecular pollutants, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F). Our center includes 3 non-biomedical projects studying the mechanism of EPFR and PCDD/F formation in thermal treatment systems, formation and fate of EPFRs in Superfund soils, and the properties of fine and ultrafine particles promoting EPFR formation. Three biomedical projects research the effects of EPFRs on oxidative stress-induced cardiac dysfunction, pulmonary dysfunction, and expression of P450. These projects are supported by 3 research cores: a Materials Core to synthesize and characterize particles to test specific research hypotheses, an Oxidative Stress Core to assess generation of ROS and oxidative stress, and a Computational Core to calculate the properties of EPFR-particle systems as a function of particle size. The program also includes, an Administrative Core, Research Translation Core, Community Outreach Core, and Training Core.

Public Health Relevance

Our researchers have discovered what is essentially a new, previously unknown pollutant-environmentally ' persistent free radicals or EPFRs. These radicals appear to be especially prone to form and reside on the surfaces of particulate matter associated with contaminated soils or the thermal treatment of hazardous substances at Superfund sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES013648-05S1
Application #
8668538
Study Section
Special Emphasis Panel (ZES1-SET-V (04))
Program Officer
Carlin, Danielle J
Project Start
2009-08-15
Project End
2016-03-31
Budget Start
2013-08-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$42,374
Indirect Cost
Name
Louisiana State University A&M Col Baton Rouge
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Huang, Huaqiong; Saravia, Jordy; You, Dahui et al. (2015) Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants. Immunol Cell Biol 93:126-35
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Schwingshackl, Andreas; Teng, Bin; Makena, Patrudu et al. (2014) Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med 42:e692-701
dela Cruz, Albert Leo N; Cook, Robert L; Dellinger, Barry et al. (2014) Assessment of environmentally persistent free radicals in soils and sediments from three Superfund sites. Environ Sci Process Impacts 16:44-52
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