Nanotechnology has great potential for development and application of novel chemical sensors and remediation approaches at Superfund and other toxic waste sites. However, nanomaterials may cause adverse health and environmental impacts during manufacturing, application, and disposal at the end of product life-cycle. A major concern in the emerging field of nanotoxicology is the analogy between commercial and noncommercial asbestos fibers and carbon nanotubes with respect to geometry, aspect ratio, rigidity, surface reactivity, and biopersistence. Identification of the fundamental physicochemical characteristics of nanomaterials relevant for their potential toxicity is required to prevent adverse health effects while retaining their unique properties for environmental sensing and remediation. An interdisciplinary research team at Brown University including a materials scientist, a toxicologic pathologist, and a molecular biologist has developed a panel of amphibole asbestos fibers, metallic nanoparticles, and carbon nanomaterials and innovative approaches for nanotoxicology assays. This panel of model nanomaterials will be expanded to include selected commercial materials subjected to rigorous characterization of toxicologically relevant materials properties. Carbon nanotubes are commercially produced in the presence of metal catalysts including Fe, Ni, or Y alone or in combination. The focus of this SBRP biomedical research project is on nickel-containing nanomaterials. Poorly-soluble nickel compounds are classified as known human carcinogens and nickel nanoparticles are highly toxic in short-term rodent lung toxicity assays. The proposed experiments will focus on the bioavailability and potential toxicity of nickel mobilized from metallic nickel nanoparticles and carbon nanotubes. The biochemical mechanisms responsible for acute toxicity of asproduced or purified commercial carbon nanotube samples will be assessed (Specific Aim 1). The potential synergistic or antagonistic effects of co-exposures to Ni plus Y catalyst residues will be assessed using human lung epithelial cells (Specific Aim 2). Finally, nickel-containing nanomaterials will be tested for activation of epigenetic pathways involved in nickel carcinogenesis (Specific Aims 3 and 4). These experiments will provide mechanistic information that will enable development of manufacturing methods and post processing steps to minimize or mitigate adverse health and environmental impacts of nanomaterials.
The over-arching goal of this Superfund Basic Research Program is to address health concerns and to design novel remediation techniques related to mixed exposures arising from contaminated lands and buildings, using Rhode Island as a model for appropriate research, educational, and training interventions.
|Qiu, Yang; Guo, Fei; Hurt, Robert et al. (2014) Explosive thermal reduction of graphene oxide-based materials: mechanism and safety implications. Carbon N Y 72:215-223|
|Shen, Rui; Suuberg, Eric M (2014) Analytical Quantification of the Subslab Volatile Organic Vapor Concentration from a Non-uniform Source. Environ Model Softw 54:1-8|
|Clift, Danielle; Richendrfer, Holly; Thorn, Robert J et al. (2014) High-throughput analysis of behavior in zebrafish larvae: effects of feeding. Zebrafish 11:455-61|
|Qin, Xiaoli; Liu, Xiaorui; Shan, Bin et al. (2014) Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice. Am J Reprod Immunol 71:229-40|
|Rodd, April L; Creighton, Megan A; Vaslet, Charles A et al. (2014) Effects of surface-engineered nanoparticle-based dispersants for marine oil spills on the model organism Artemia franciscana. Environ Sci Technol 48:6419-27|
|Velazquez-Jimenez, Litza Halla; Hurt, Robert H; Matos, Juan et al. (2014) Zirconium-carbon hybrid sorbent for removal of fluoride from water: oxalic acid mediated Zr(IV) assembly and adsorption mechanism. Environ Sci Technol 48:1166-74|
|Catlin, Natasha R; Huse, Susan M; Boekelheide, Kim (2014) The stage-specific testicular germ cell apoptotic response to low-dose radiation and 2,5-hexanedione combined exposure. II: qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. Toxicol Pathol 42:1229-37|
|Catlin, Natasha R; Huse, Susan M; Boekelheide, Kim (2014) The stage-specific testicular germ cell apoptotic response to low-dose X-irradiation and 2,5-hexanedione combined exposure. I: Validation of the laser capture microdissection method for qRT-PCR array application. Toxicol Pathol 42:1221-8|
|Shen, Rui; Pennell, Kelly G; Suuberg, Eric M (2014) Analytical modeling of the subsurface volatile organic vapor concentration in vapor intrusion. Chemosphere 95:140-9|
|Sharma, Surendra (2014) Natural killer cells and regulatory T cells in early pregnancy loss. Int J Dev Biol 58:219-29|
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