The Analytical Core is comprised of two research support activities;chemistry and biostatistics. The goals of the core are to provide technical expertise, a support staff, and research tools necessary to make quantitative assessments of the chemicals that will be studied in this project, and to evaluate the exposures and risks associated with these chemicals. The Chemistry component of the Core will use an existing infrastructure of instrumentation and technical support associated with Brown University's Environmental Chemistry Facility to provide a managed set of laboratories and analytical facilities that will be shared among all the research projects to detect and quantify organic and inorganic compounds that are considered hazardous to human health. The Biostatistical component will provide statistical methodology and computational support for experimental design and data analysis for the research projects. The expertise from the two components will also be integrated to ensure comprehensive analysis of the chemicals and their health risks. There are five specific aims proposed in the Analytical Core: 1) Provide centralized facilities for the analysis of organic and inorganic compounds, and for biostatistical analysis;2) Provide a Leader who will be responsible for the management of the chemistry component of the Core and a Leader who will be responsible for the biostatistical capabilities;3) Provide the knowledge base and personnel to support investigators in the development of appropriate and innovative techniques to satisfy their specific analytical chemistry and biostatiistical goals;4) Provide expendable supplies, equipment parts, and the computational capabilities to maintain a state-of-the-art facility;and 5) Provide training for students, technicians, and researchers using core facilities. During the initial award period, funds were available to enhance the analytical capabilities of the instruments and facilities specifically focused on the detection and quantification of organic compounds, and mercury analysis of vapors, liquids, and solids. Accomplishment of Aims 1-5 will use the existing infrastructure at Brown, and a knowledge base and support staff for machine maintenance, computational analyses, and training. This model of management has worked well during the initial funding period and will continue to support the research projects in this study and the analytical facilities that will be shared among the projects

Public Health Relevance

The over-arching goal of this Superfund Basic Research Program is to address health concerns, and to design novel remediation techniques, related to mixed exposures arising from contaminated lands and buildings, using Rhode Island as a model for appropriate research, educational, and training interventions. In support of the proposed research, the Analytical Core will provide the necessary analytical tools and technical expertise to detect and quantify the toxicants that will be studied in this project, and to develop the technical and bioinformatics tools and procedures to evaluate the exposures and risks.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Special Emphasis Panel (ZES1-LKB-D)
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Brown University
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Zhu, Wenpeng; von dem Bussche, Annette; Yi, Xin et al. (2016) Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proc Natl Acad Sci U S A 113:12374-12379
Dere, Edward; Wilson, Shelby K; Anderson, Linnea M et al. (2016) From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure. Toxicol Sci 153:327-40
Gonzalez, Sarah T; Remick, Dylan; Creton, Robbert et al. (2016) Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish. Neurotoxicology 53:93-101
Pennell, Kelly G; Scammell, Madeleine K; McClean, Michael D et al. (2016) Field data and numerical modeling: A multiple lines of evidence approach for assessing vapor intrusion exposure risks. Sci Total Environ 556:291-301
Verginelli, Iason; Yao, Yijun; Wang, Yue et al. (2016) Estimating the oxygenated zone beneath building foundations for petroleum vapor intrusion assessment. J Hazard Mater 312:84-96
Lovato, Ava K; Creton, Robbert; Colwill, Ruth M (2016) Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on larval zebrafish behavior. Neurotoxicol Teratol 53:1-10
Kuempel, Eileen D; Jaurand, Marie-Claude; Møller, Peter et al. (2016) Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Crit Rev Toxicol :1-58
Holden, Patricia A; Gardea-Torresdey, Jorge L; Klaessig, Fred et al. (2016) Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials. Environ Sci Technol 50:6124-45
Dere, E; Huse, S; Hwang, K et al. (2016) Intra- and inter-individual differences in human sperm DNA methylation. Andrology 4:832-42
Wang, Zhongying; Zhu, Wenpeng; Qiu, Yang et al. (2016) Biological and environmental interactions of emerging two-dimensional nanomaterials. Chem Soc Rev 45:1750-80

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