In this project we assess exposures to atmospheric PCBs among a cohort of children and their mothers in a contaminated area where dredging of PCB-laden sediments will occur during the study period. PCB concentrations are measured through repeated air sampling inside and outside of homes and local schools. Blood samples are collected annually and assayed for PCB congeners. These data are compared to a rural site to characterize high and low exposure residential cohorts. The urban site (East Chicago, IN) has a legacy of PCB contamination from intense past industrial activity whereas the rural site (Columbus Junction, IA) is without local sources of PCBs. The project will continue four original aims and pursue two new aims:
Aim 1. Establish a residential cohort in East Chicago and a rural residential cohort in Columbus Junction;
Aim 2. Measure emissions and exposures of atmospheric PCBs at homes and schools in these communities;
Aim 3. Gather demographic, residential, occupational, activity and dietary information by questionnaire;
Aim 4. Analyze data from these cohorts and develop an exposure model for the atmospheric PCB congeners.
Aim 1 has been achieved but we will to expand the cohort to increase power and span the time before and during the dredging.
Aim 2 and Aim 3 are ongoing. We continue to measure subjects'PCB exposures, collect blood samples and administer questionnaires. We have begun Aim 4 with analysis of survey data and congener-specific PCBs. Two new aims are planned for this renewal.
Aim 5. Measure congener-specific hydroxy metabolites of PCBs in subjects'biobanked extracted and derivitized blood samples.
Aim 6. Adapt a bioaccumulation model to predict the PCB body burden in subjects breathing air with measured PCBs levels and compare modelled data with measured data. Five hypotheses will be tested: H1: East Chicagoans have significantly higher exposures, and (H2) blood levels of atmospheric PCB congeners than rural lowans. H3: Adolescent's burdens of PCB congeners are significantly correlated with those of their mothers. H4: East Chicagoans will experience increased exposures with the dredging of Indiana Harbor and Ship Canals and filling of the Confined Disposal Facility. H5: Bioaccumulation models can predict the relative body burdens of PCBs using measured air data and dietary questionnaire data.

Public Health Relevance

The primary goal of the project is to compare airborne exposures to PCBs between high and low exposure community cohorts and determine the importance of inhalation exposure to the body burden. A second goal is to determine if residential populations living near dredging operations are at increased risk of exposure to atmospheric PCBs.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LWJ-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Iowa City
United States
Zip Code
Liang, Yi; Meggo, Richard; Hu, Dingfei et al. (2014) Enhanced Polychlorinated Biphenyl Removal in a Switchgrass Rhizosphere by Bioaugmentation with Burkholderia xenovorans LB400. Ecol Eng 71:215-222
Yang, Shupeng; Shi, Weimin; Hu, Dingfei et al. (2014) In vitro and in vivo metabolite profiling of valnemulin using ultraperformance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry. J Agric Food Chem 62:9201-10
Salman, Kadhim N; Stuart, Mary A; Schmidt, Jack et al. (2014) The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum. Environ Sci Pollut Res Int 21:6400-9
Tehrani, Rouzbeh; Lyv, Monica M; Van Aken, Benoit (2014) Transformation of hydroxylated derivatives of 2,5-dichlorobiphenyl and 2,4,6-trichlorobiphenyl by Burkholderia xenovorans LB400. Environ Sci Pollut Res Int 21:6346-53
Vorrink, Sabine U; Severson, Paul L; Kulak, Mikhail V et al. (2014) Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274:408-16
Ekuase, Edugie J; Lehmler, Hans-Joachim; Robertson, Larry W et al. (2014) Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64
Wu, Xianai; Kammerer, Austin; Lehmler, Hans-Joachim (2014) Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48:2436-44
Shen, Hua; Li, Miao; Wang, Bingxuan et al. (2014) Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Environ Sci Pollut Res Int 21:6384-99
Hu, Xin; Adamcakova-Dodd, Andrea; Thorne, Peter S (2014) The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100
Sueyoshi, Tatsuya; Li, Linhao; Wang, Hongbing et al. (2014) Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137:292-302

Showing the most recent 10 out of 171 publications