The plans and activities of the Research Translation Core (RTC or Core) of the lowa superfund basic research program (isbrp) are designed with four aims in mind. The first is to contribute to the development of sound public policies and practices (Aim 1);second, to contribute to the research base in our disciplines (Aim 2);third, to contribute to a broader public understanding of problems and solutions regarding environmental hazards and their remediation (Aim 3);and fourth, to formally transfer technology to commercial enterprises able to develop and deliver products or services to the public (Aim 4). Public policy has been advanced by two workshops which together brought more than 30 Midwest elected officials and legislative staff into dialogue with scientists from the isbrp as well as state and federal environmental officials. Research translation to the academic community has been strengthened by a 80 peer reviewed publications and numerous presentations at conferences. Several newspaper articles have described work of center scientists in and around the Chicago area. Highlights of several research findings have been released in publications targeted to a scientific and technical audience. In addition, parents of students in focus communities have seen the work of their children and many are taking part in an exposure study in two towns. Technology transfer to commercial enterprises is ongoing through interaction with RTC staff and isbrp scientists and the University of lowa Research Foundation. These aspects of significant research translation will be sustained and developed further with the guidance of the Research Translation Advisory Committee. This Core will work in close coordination with the Community Outreach Core (COC), especially on the COC plans to support implementation of Research Project #6 in East Chicago, Indiana and Columbus Junction, lowa. RTC personnel have broad experience in all aspects of research translation especially in translating isbrp research to policy makers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES013661-08
Application #
8451612
Study Section
Special Emphasis Panel (ZES1-LWJ-M)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
8
Fiscal Year
2013
Total Cost
$105,644
Indirect Cost
$39,630
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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Herkert, Nicholas J; Hornbuckle, Keri C (2018) Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environ Sci Process Impacts 20:757-766
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Dhakal, Kiran; Gadupudi, Gopi S; Lehmler, Hans-Joachim et al. (2018) Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290
Enayah, Sabah H; Vanle, Brigitte C; Fuortes, Laurence J et al. (2018) PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology 394:93-101
Klinefelter, Kelsey; Hooven, Molly Kromme; Bates, Chloe et al. (2018) Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 29:112-127
Gourronc, Francoise A; Robertson, Larry W; Klingelhutz, Aloysius J (2018) A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492
Alam, Sinthia; Carter, Gwendolyn S; Krager, Kimberly J et al. (2018) PCB11 Metabolite, 3,3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD. Antioxidants (Basel) 7:
Li, Xueshu; Holland, Erika B; Feng, Wei et al. (2018) Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25:16508-16521
Sethi, Sunjay; Keil, Kimberly P; Lein, Pamela J (2018) 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 92:3337-3345

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