During the last decades human ingenuity and activity have unfortunately resulted in the proliferation and the release of new man-made chemicals into the environment. As we now know, such pollution problems are not isolated and local, but found in every nation. This poses a magnitude of new questions like: Are these pollutants transported by air or water to distant locations? Are they harmful to human health? Do they threaten more sensitive wildlife species? How can we detect contamination in the environment? What can we do to hasten their destruction? Since environmental contamination touches everyone's life, it also raises other issues for scientists and engineers such as which laws deal with this issue? Which state, federal or international agencies should be involved? How can scientists and engineers inform and work with the public to alleviate fear and/or prevent harm? Solutions to environmental problems are therefore a team effort. Thus, future scientists and engineers need (i) thorough training in their specific field, (ii) basic knowledge about socioeconomic, legal, engineering and science aspects outside their field, and (iii) an ability to communicate and cooperate with specialists in other disciplines and societies. These are the goals of the proposed Cross- Disciplinary Training "Without Borders" core project. This training core builds on successful collaborations among the isbrp faculty and with international colleagues. It enhances and establishes new activities among these scientists that promote cross-disciplinary education, and use new information technology to connect students and faculty around the world. Graduate students and postdocs are recruited into the program based on their ability, motivation and academic record. Emphasis is placed on identifying and recruiting qualified individuals from underrepresented groups in science and engineering. Other students, post-docs and professionals are encouraged to participate by using modern information technology. The outstanding achievements of our students and postdocs in the first 3 years of this isbrp demonstrate that the Training Core achieved its mission. The continuing extremely generous financial support of the Graduate College, even in these challenging times, shows the confidence of Ul in the Training Core. This isbrp has the ideal basis to train the scientist for the 21st century.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-LWJ-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Iowa City
United States
Zip Code
Liang, Yi; Meggo, Richard; Hu, Dingfei et al. (2014) Enhanced Polychlorinated Biphenyl Removal in a Switchgrass Rhizosphere by Bioaugmentation with Burkholderia xenovorans LB400. Ecol Eng 71:215-222
Yang, Shupeng; Shi, Weimin; Hu, Dingfei et al. (2014) In vitro and in vivo metabolite profiling of valnemulin using ultraperformance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry. J Agric Food Chem 62:9201-10
Salman, Kadhim N; Stuart, Mary A; Schmidt, Jack et al. (2014) The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum. Environ Sci Pollut Res Int 21:6400-9
Tehrani, Rouzbeh; Lyv, Monica M; Van Aken, Benoit (2014) Transformation of hydroxylated derivatives of 2,5-dichlorobiphenyl and 2,4,6-trichlorobiphenyl by Burkholderia xenovorans LB400. Environ Sci Pollut Res Int 21:6346-53
Vorrink, Sabine U; Severson, Paul L; Kulak, Mikhail V et al. (2014) Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274:408-16
Ekuase, Edugie J; Lehmler, Hans-Joachim; Robertson, Larry W et al. (2014) Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64
Wu, Xianai; Kammerer, Austin; Lehmler, Hans-Joachim (2014) Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48:2436-44
Shen, Hua; Li, Miao; Wang, Bingxuan et al. (2014) Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Environ Sci Pollut Res Int 21:6384-99
Hu, Xin; Adamcakova-Dodd, Andrea; Thorne, Peter S (2014) The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100
Sueyoshi, Tatsuya; Li, Linhao; Wang, Hongbing et al. (2014) Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137:292-302

Showing the most recent 10 out of 171 publications