The 20th century brought the chemical revolution and the steady increase of large scale production of chemicals. Only later did the problem of environmental persistence of some of these new and useful chemicals become evident, and only recently did we discover the magnitude of the negative health effects of these persistent pollutants, ranging from an involvement in the increase in brain diseases and metabolic syndrome, to cancer, fertility problems, reduced function of the immune system, and even hearing loss and autism. Moreover, these pollutants may volatilize, contaminate indoor and outdoor air, and travel large distances across borders and continents. Meanwhile, society must deal with these legacy contaminants, inform affected populations, protect humans and the environment, and prevent ongoing and future contamination. To be successful, environmental health and engineering professionals have to deal with these problem chemicals in multiple dimensions. The traditional training approach designed to produce specialized experts in individual, narrow disciplines is clearly inappropriate to prepare trainees for leadership roles in environmental health and technology. Instead, future scientists and engineers need thorough training in their specific fields, basic knowledge about socioeconomic, legal, engineering and science aspects outside their fields, and an ability to communicate and cooperate with specialists in other disciplines and with various stakeholders and affected groups. The goal of the Training Core of the Iowa Superfund Research Program (isrp) is to prepare students through holistic, cross-disciplinary training Without Borders for these challenges. To achieve these goals, the Training Core strives to: 1) recruit excellent, highly motivated trainees into Superfund research, 2) promote cross disciplinary didactic education, 3) support existing and the development of new interdisciplinary research by trainees, and 4) provide trainees with experiences beyond the curriculum and research to prepare them for a successful transition into professional life and ability to effectively interact with diverse audiences. In the last funding circle (2010-now), 52 graduate students and 20 postdocs obtained such training (26 of these are still ongoing). This was possible because of the established, successful and supportive collaborations among the isrp faculty members who represent diverse areas of expertise such as toxicology, occupational & environmental health, free radical biology, medicinal pharmacology, environmental engineering and urban & regional planning. In addition, the Training Core is blessed with significant support from the Graduate College of the University of Iowa. The outstanding achievements of our students and postdocs in the years since this isrp was founded and the exceptional diversity of isrp trainees, including minorities and a multitude of ethnicities and nationalities, demonstrate that the Core is achieving its mission of training the scientists and engineers for the 21st century who work across all borders to solve the problems of hazardous chemicals.

Public Health Relevance

Our lives have become so much safer and more convenient through chemistry, but the flood of new, mass produced chemicals and of persistent and potentially harmful legacy compounds require a new breed of experts for chemical stewardship, scientists and engineers that are experts in their field but can understand and work with colleagues from other fields, communicate with stakeholders and affected populations, and understand social and legal aspects. The Superfund Research Program is the ideal environment to provide the cross-disciplinary and `expanded' training needed to produce such experts, and this Training Core is working with the uniquely productive, diverse and cooperative team of researchers of the Iowa Superfund Research Program, taking advantage of their extensive expertise in training and of the exemplary support from the University of Iowa Graduate College to train graduate students and postdocs. The outstanding achievements of our students and postdocs in the years since this isrp was founded, and the exceptional diversity of isrp trainees, demonstrate that the Training Core is achieving its mission to train scientists and engineers for the 21st century, which can and will work across all disciplinary, societal and national borders to solve the problems associated with harmful contaminats.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES013661-14
Application #
9672922
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
14
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Hou, Xingwang; Yu, Miao; Liu, Aifeng et al. (2018) Biotransformation of tetrabromobisphenol A dimethyl ether back to tetrabromobisphenol A in whole pumpkin plants. Environ Pollut 241:331-338
Xiao, Xin; Chen, Baoliang; Chen, Zaiming et al. (2018) Insight into Multiple and Multilevel Structures of Biochars and Their Potential Environmental Applications: A Critical Review. Environ Sci Technol 52:5027-5047
Herkert, Nicholas J; Jahnke, Jacob C; Hornbuckle, Keri C (2018) Emissions of Tetrachlorobiphenyls (PCBs 47, 51, and 68) from Polymer Resin on Kitchen Cabinets as a Non-Aroclor Source to Residential Air. Environ Sci Technol 52:5154-5160
P?n?íková, Kate?ina; Svržková, Lucie; Strapá?ová, Simona et al. (2018) In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486
P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Robertson, Larry W; Weber, Roland; Nakano, Takeshi et al. (2018) PCBs risk evaluation, environmental protection, and management: 50-year research and counting for elimination by 2028. Environ Sci Pollut Res Int 25:16269-16276
Klaren, William D; Vine, David; Vogt, Stefan et al. (2018) Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25:16427-16433
Tomsho, Kathryn S; Basra, Komal; Rubin, Staci M et al. (2018) Correction to: Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25:16401
Uwimana, Eric; Li, Xueshu; Lehmler, Hans-Joachim (2018) Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite. Environ Sci Technol 52:6000-6008
Herkert, Nicholas J; Hornbuckle, Keri C (2018) Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environ Sci Process Impacts 20:757-766

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